Testing Exendin PET, a new imaging technique, for imaging paragangliomas
- Conditions
- paragangliomas
- Registration Number
- 2024-516755-40-00
- Lead Sponsor
- Stichting Radboud universitair medisch centrum
- Brief Summary
The main study aim of the study is to examine the feasibility of detecting PGLs using 68Ga-exendin-4 PET/CT.
- Detailed Description
Rationale:
Functional imaging of paragangliomas (PGLs) is not unequivocal. Existing functional imaging modalities show good but variable results in PGLs, warranting the search for additional molecular imaging targets. Investigators aim to evaluate the glucagon-like peptide 1 receptor (GLP-1R) as a novel target for molecular imaging of PGLs. For this purpose investigators will use the tracer 68Ga-NODAGA-exendin 4 for positron emission tomography/computed tomography (PET/CT) imaging.
Objective:
The primary objective is to examine the feasibility of 68Ga-exendin-4 PET/CT for localization and functional characterization of PGLs.
Study design:
In this prospective pilot imaging study 68Ga-exendin-4 PET/CT will be performed in 10 patients with confirmed PGL who have undergone CT, somatostatin receptor (SSTR) PET/CT and 18F-FDG PET/CT (as standard diagnostic procedures) and are scheduled for surgery. 100 ± 10 MBq 68Ga-NODAGA-exendin-4 will be administered to 10 patients in total. In the first 5 patients PET/CT imaging will be performed 1, 2 and 4 hours after injection to determine the optimal imaging timepoint for the remainder of the patients, which will be applied in the remaining patients.
The images will be reconstructed and evaluated by a nuclear medicine physician who is blinded to the results of the CT, SSTR PET/CT and 18F-FDG PET/CT to assess tumor detection. Additionally, quantitative analysis of 68Ga-exendin-4, SSTR PET and 18F-FDG PET/CT images will be performed. After the patients have undergone surgery, immunohistochemical analysis of surgical specimens will be performed to assess GLP-1R expression, which will be compared with in vivo tracer uptake.
Recruitment & Eligibility
- Status
- Authorised, recruitment pending
- Sex
- Not specified
- Target Recruitment
- 10
• Proven sympathetic PGL with a single tumor detected using standard diagnostic imaging
• No evidence of metastatic disease
• CT and SSTR PET/CT performed (golden standard diagnostic imaging)
• Scheduled for surgery
• Able to sign informed consent
• Breast feeding
• Pregnancy or the wish to become pregnant within 1 month
• Calculated creatinine clearance below 40ml/min
• Evidence of other malignancy than PGL in conventional imaging (suspicious liver, bone and lung lesions)
• Age < 18 years
• Not able to sign informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detection rate of PGLs (paragangliomas) using 68Ga-exendin-4 PET/CT Detection rate of PGLs (paragangliomas) using 68Ga-exendin-4 PET/CT
- Secondary Outcome Measures
Name Time Method optimal timepoint for imaging PGLs using 68Ga-exendin-4 PET/CT optimal timepoint for imaging PGLs using 68Ga-exendin-4 PET/CT
Comparison of quantitative imaging paramters (SUV, tumor-to-background ratio, contract-to-noise ratio) between Optimal timepoint for imaging PGLs using 68Ga-exendin-4 PET/CT, 18F-FDG PET and SSTR PET Comparison of quantitative imaging paramters (SUV, tumor-to-background ratio, contract-to-noise ratio) between Optimal timepoint for imaging PGLs using 68Ga-exendin-4 PET/CT, 18F-FDG PET and SSTR PET
correlation between GLP-1R expression and tracer uptake in the PGLs correlation between GLP-1R expression and tracer uptake in the PGLs
Correlation quantitative imaging results and IHC data to the genetic origin of the PGLs Correlation quantitative imaging results and IHC data to the genetic origin of the PGLs
Trial Locations
- Locations (1)
Radboud universitair medisch centrum Stichting
🇳🇱Nijmegen, Netherlands
Radboud universitair medisch centrum Stichting🇳🇱Nijmegen, NetherlandsSevilay TokgözSite contact0031243655340sevilay.tokgoz@radboudumc.nl