To assess if the use of EEG monitoring during anaesthesia i.e. Entropy monitoring can help in assessing propofol requirement in patients undergoing laryngeal surgery under total intravenous anaesthesia with or without the use of an additive drug dexmedetomidine
Phase 3
Completed
- Conditions
- Health Condition 1: J38- Diseases of vocal cords and larynx, not elsewhere classifiedHealth Condition 2: null- Patients aged 18-65 years undergoing surgery performed on the larnyx using suspension laryngoscopy
- Registration Number
- CTRI/2013/05/003605
- Lead Sponsor
- Anjolie Chhabra
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
This study will be conducted in the Department of Anaesthesiology at All India Institute of Medical Sciences after obtaining Institutional Ethics committee approval. 60 ASA I and II patients, 18-65 years, undergoing laryngotracheal procedures requiring suspension laryngoscopy, rigid bronchoscopy will be included in this study after taking informed consent
Exclusion Criteria
1.Patients who have neurological deficit following head injury, epilepsy etc. which can interfere with entropy monitoring.
2. Patients who are morbidly obese (BMI >35kg/m2).
3. Patients on β blockers, clonidine, verapamil.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary aim of the study is to evaluate the effect-site concentration (Ce) of propofol needed for laryngeal surgeries by using the entropy monitor to titrate the depth of anesthesiaTimepoint: the study involves titrating intraoperative requirement of propofol
- Secondary Outcome Measures
Name Time Method To assess- <br/ ><br>1. if the target controlled infusion (TCI) propofol requirement during total intravenous anaesthesia(TIVA) is decreased with the concomittant use of dexamedetomidine infusion <br/ ><br>2. whether concomittant use of dexmedetomidine with the TCI-TIVA propofol results in faster awakening of patients after laryngeal surgery <br/ ><br>3. if the concomittant use of dexmedetomidine with the TCI-TIVA propofol results in lesser intraoperative haemodynamic variations in patients undergoing laryngeal surgery.Timepoint: Intraoperative requirement of the drugs will be titrated