Evaluation of the Effect of Mediterranean Diet on Breast Cancer Patients
- Conditions
- Breast Cancer
- Interventions
- Behavioral: Mediterranean Diet
- Registration Number
- NCT04818996
- Lead Sponsor
- Aydin Adnan Menderes University
- Brief Summary
In this study, it was aimed to evaluate the effect of the Mediterranean diet on body composition, oxidant stress and proinflammatory markers in overweight and obese breast cancer women.
- Detailed Description
Breast cancer is the most common type of cancer among women in both developed and developing countries and is the leading cause of cancer death among women worldwide. Breast cancer is a disease that can develop and progress for various reasons. In addition to unchangeable factors such as increasing age and genotype, modifiable factors such as smoking, alcohol consumption, lack of physical activity, malnutrition, and obesity play a role in the pathogenesis of the disease.
Breast cancer risk increases with increasing body mass index (BMI) in postmenopausal women. Chronic inflammation in obesity is associated with an increase in the release of proinflammatory factors (such as TNF-α, IL-1, IL-6). This situation; It is a risk factor for many types of cancer such as colon, stomach, breast and prostate carcinomas and supports a cause-effect relationship between obesity and cancer. These proinflammatory factors act as signal converters for tumor growth and progression. Obese women have elevated levels of TNF-α and IL-6 in the circulation, and this is associated with the development and progression of breast tumors.
The Mediterranean Diet, which consists of high amounts of monounsaturated fatty acids, fruits, vegetables and whole grains, has been widely evaluated and indicated as an important factor in preventing tumor formation from inflammatory pathways.
Weight loss improves the antitumor immune system, lowers estrogen levels, reduces the risk of breast cancer and has been associated with better outcomes in obese patients. Lifestyle intervention studies strongly suggest that weight loss is possible and observational studies can actually improve breast cancer survival.In this regard, a healthy lifestyle and diet are the first steps to prevent breast cancer.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 25
- At least 18 years old,
- BMI value to be ≥25 kg/m2,
- To be diagnosed with breast cancer stage I, II or III,
- Being a positive hormone receptor status, one of the biological subtypes of breast cancer,
- Having completed chemotherapy and / or radiotherapy treatment at least 6 months before starting the study,
- Not applying any treatment for body weight loss,
- Accepting to participate in the study,
- Perceiving disorder and not having communication problems.
- Being under the age of 18 and over the age of 65,
- BMI value to be 40 kg/m2,
- Having advanced stage breast cancer (IV and V),
- Being diagnosed with cancer or metastasis in other organs,
- Being one of the biological subtypes of breast cancer, hormone receptor status being negative,
- Using antioxidant vitamin-mineral supplements,
- Using herbal supplements,
- Being pregnant or planning a pregnancy,
- To stop working after starting diet therapy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Mediterranean Diet Mediterranean Diet In the study, the participants were applied a diet compatible with the Mediterranean diet for 8 weeks.
- Primary Outcome Measures
Name Time Method Change in resting metabolic rate (RMR) measured by bioelectrical impedance analyzer Baseline, 8 weeks RMR (kcal) was measured using the InBody 270 brand device.
Change in interleukin 6 (IL-6) Baseline, 8 weeks Blood was drawn from participants for assessment of IL-6 (pg/mL) at the beginning and end of the study after fasting for at least 8 hours
Change in total antioxidant status (TAS) Baseline, 8 weeks Blood was drawn from participants for assessment of TAS (mmol/L) at the beginning and end of the study after fasting for at least 8 hours
Change in fat-free mass measured by bioelectrical impedance analyzer Baseline, 8 weeks Fat-free mass (kg) was measured using the InBody 270 brand device.
Change in malondialdehyde (MDA) Baseline, 8 weeks Blood was drawn from participants for assessment of MDA (mmol/L) at the beginning and end of the study after fasting for at least 8 hours
Change in body weight Baseline, 8 weeks Body weight (kg) was measured using the InBody 270 brand device.
Change in body mass indexs Baseline, 8 weeks The BMI is defined as the body mass divided by the square of the body height, and is expressed in units of kg/m\^2, resulting from mass in kilograms and height in metres.
Change in tumor necrosis factor alpha (TNF-α) Baseline, 8 weeks Blood was drawn from participants for assessment of TNF-α (pg/mL) at the beginning and end of the study after fasting for at least 8 hours
Change in total oxidant status (TOS) Baseline, 8 weeks Blood was drawn from participants for assessment of TOS (µmol/L) at the beginning and end of the study after fasting for at least 8 hours
Change in fat mass measured by bioelectrical impedance analyzer Baseline, 8 weeks Fat mass (kg) was measured using the InBody 270 brand device.
- Secondary Outcome Measures
Name Time Method Change in oxidative stress index (OSI) Baseline, 8 weeks The oxidative stress index (OSI) value expressed as a percentage of the ratio of serum total oxidant status (TOS) levels to total antioxidant status (TAS) levels was calculated.
Change in waist circumference Baseline, 8 weeks Waist circumference (cm) was measured with a non-stretch tape measure.
Change in hip circumference Baseline, 8 weeks Hip circumference (cm) was measured with a non-stretch tape measure.
Change in dietary inflammatory index (DII) Baseline, 8 weeks Dietary inflammatory index (DII) was calculated with 3-day food consumption record.
Trial Locations
- Locations (1)
Aydın Adnan Menderes University, Faculty of Health Sciences, Department of Nutrition and Dietetics
🇹🇷Aydın, Efeler, Turkey