The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9

• Conditions: Healthy; Exercise
• Interventions: Other: Physiological test; Other: Physical test; Other: Biochemical tests

• Registration Number: NCT05117437
• Lead Sponsor: Ege University

Brief Summary

Bone morphogenetic protein (BMP) 9 from the BMP family has an important role in the remodeling of bone and cartilage. Due to these features, BMP9 can play an important role in especially anaerobic exercise training adaptations. However, the role of anaerobic exercise in these effects is still unclear. The aim of this study is to investigate the role of BMP9 on the effects of acute and chronic anaerobic exercise on bone metabolism markers. Postprandial venous blood samples were taken pre- and post- acute YOYO intermittent recovery test (level 1) in 40 trained male athletes aged 18-35 who did anaerobic sports (such as basketball, volleyball and handball) and 41 sedentary volunteers aged 18-35. Serum BMP9, as markers of bone formation and resorption; alkaline phosphatase (ALP), C-terminal telopeptide of type 1 collagen (CTX1), cartilage oligomeric matrix protein (COMP) and calcium levels were determined. The data to be obtained as a result of our study can give information about the relationship between the skeletal and bone health of the athletes and anaerobic exercise.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-03
• Primary Completion: 2021-06-01
• Study First Submitted: 2021-10-11
• Status Verified: 2021-11
• Study First Submitted QC: 2021-11-02
• Last Update Submitted: 2021-11-02
• Study First Posted: 2021-11-11
• Last Update Posted: 2021-11-11
• Study Completion: 2021-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 81

Inclusion Criteria

• being male
• having a body mass index of less than 30 being

Exclusion Criteria

• to have some disease or disability
• to regularly use cigarettes and alcohol
• to use any medication or antioxidant substance

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Athletic group	Physiological test	Healthy male athletes who have been doing regular anaerobic sports (such as basketball, volleyball and handball) for at least 3 months
Control group	Physical test	Healthy sedentary (not doing regular sports for at least 3 months) men with age and physical characteristics similar to the athlete group
Athletic group	Biochemical tests	Healthy male athletes who have been doing regular anaerobic sports (such as basketball, volleyball and handball) for at least 3 months
Control group	Physiological test	Healthy sedentary (not doing regular sports for at least 3 months) men with age and physical characteristics similar to the athlete group
Athletic group	Physical test	Healthy male athletes who have been doing regular anaerobic sports (such as basketball, volleyball and handball) for at least 3 months
Control group	Biochemical tests	Healthy sedentary (not doing regular sports for at least 3 months) men with age and physical characteristics similar to the athlete group

Primary Outcome Measures

Name	Time	Method
Change from serum CTX1 levels at pre- and post- YOYO intermittent test	between 40-50 minutes	Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum C-terminal telopeptide of Type 1 collagen (CTX1) was determined.
Change from serum BMP9 levels at pre- and post- YOYO intermittent test	between 40-50 minutes	Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum Bone morphogenetic protein 9 (BMP9) was determined.
Change from serum COMP levels at pre- and post- YOYO intermittent test	between 40-50 minutes	Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum cartilage oligomeric matrix protein (COMP) was determined.

Trial Locations

Locations (1)

Ege University Faculty of Sport Sciences; 🇹🇷 İzmir, Turkey