Superior venacaval oxygen saturation monitoring (Intermittent / Continuous) based Goal Directed Therapy vs Standard Care in Children with Septic Shock: An Open Label Randomized Control Trial

PGIMER0 个研究点目标入组 92 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•i. All children >= 6 month to <12 years
•ii. Presenting to Pediatric ER with clinical septic shock
•iii. Developing it within 24 hours of admission to Pediatric ER
•Septic shock will be defined by presence of clinically suspected sepsis with cardiovascular organ dysfunction i.e., children with persistent hypotension (MAP <5th centile for age and gender) despite 40 ml/kg of resuscitation fluid and requiring vasoactive drug infusion during first 1 hour.

•i. Contraindications for central neck venous line insertion (IJV or Subclavian vein) like bleeding tendencies, or not accessible for line insertion due to short neck or local disease.
•ii. Children already on inotrope with inotrope score of >10 at arrival to our hospital.
•iii. Children with known or suspected congenital heart disease
•iv. Immunocompromised patients, e.g., primary immunodeficiency disorders, HIV (exposed or positive), patients with malignancies or other diseases on immunosuppressive medications including steroids.
•v. Children with chronic illness like tuberculosis, chronic liver disease, chronic kidney disease, chronic respiratory disease etc.
•vi. Known Inborn errors of metabolism
•vii. Children with shock primarily due to diarrhea and severe dehydration.
•viii.Children with suspected healthcare associated infection

发起方