The Timing of Prophylactic Antibiotics in Cesarean Section and the Risk of Post-operative Febrile Morbidity
Phase 4
Terminated
- Conditions
- Cesarean Section
- Registration Number
- NCT00133029
- Lead Sponsor
- University of Pennsylvania
- Brief Summary
The purpose of this study is to determine whether the timing of prophylactic antibiotic administration for cesarean section (immediate preoperative versus intraoperative administration) impacts the rate of postoperative febrile morbidity. The specific aim of the project is to test the hypothesis that preoperative antibiotic administration will decrease the rate of composite postoperative febrile morbidity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
- Gestational age > 36 weeks
- Ability to understand requirements of the study
- Elective/non-emergent cesarean section selected as route of delivery by treating physicians
Exclusion Criteria
- Known fetal anomaly
- Exposure to antibiotics within 7 days of admission, including intrapartum group B streptococcal (GBS) prophylaxis
- Emergent cesarean delivery (i.e. for fetal distress, maternal distress, obstetric hemorrhage)
- Overt maternal intrapartum infection requiring antibiotics
- Prolonged rupture of membranes (>18 hours)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms of preoperative versus intraoperative cefazolin administration in reducing postoperative febrile morbidity after cesarean section?
How does preoperative versus intraoperative administration of beta-lactam antibiotics affect postoperative febrile morbidity in cesarean sections?
Which inflammatory biomarkers predict response to preoperative versus intraoperative antibiotic timing in cesarean sections?
What are the adverse event profiles and management strategies for preoperative versus intraoperative antibiotic timing in cesarean sections?
What is the real-world effectiveness of preoperative versus intraoperative antibiotic administration in cesarean sections for preventing febrile morbidity as studied by the University of Pennsylvania?
Trial Locations
- Locations (1)
Hospital of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Hospital of the University of Pennsylvania🇺🇸Philadelphia, Pennsylvania, United States