eural responses following rTMS in MDD

Phase 2

• Conditions: Patients (Major depressive disorder and bipolar II disorder) and healthy controls

• Registration Number: JPRN-jRCTs052180035
• Lead Sponsor: Murai Toshiya

Brief Summary

High frequency rTMS for the left dorsolateral prefrontal cortex suggests improvement in depressive symptoms.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-01-29
• Study Completion: 2019-09-30
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

Patients
1. Aged 20-75 years-old, male and female
2. Diagnosis of major depressive disorder or bipolar II disorder
3. Current diagnosis of major depressive episode
4. HAMD_17 >=14 or BDI >=20
5. resistent to medication (including medication intolerance)
6. Capability of informed consent

Healthy controls
1. Aged 20-75 years-old, male and female without psychiatric disorder
2. No family history of major depressive disorder and bipolar disorder in their first relatives
3. Capability of informed consent

Exclusion Criteria

Patients and healthy controls
1. Implanted cardiac pacemaker
2. Surgical aneurysm clips
3. Neurostimulator
4. Implanted pumps
5. Metal fragments in body
6. Subjects who are contraindicated for the use of MRI [e.g. Tattoos, permanent eyeliner (if ink contains metallic specks)]
7. Diagnosis of neurological disorders (including epilepsy), substance dependence, or current serious medical illness (e.g. severe cardiac disease)
8. History of neurological disorders (including epilepsy), substance dependence, or head injury with loss of consciousness
9. Subjects with pregnancy or during lactation.
10. Subjects who are judged as unsuitable for participation in this study

Study & Design

• Study Type: Interventional
• Study Design: Not specified