Blood Flow Restriction Training for Age-Related Sarcopenia

Not Applicable

Not yet recruiting

• Conditions: Sarcopenia in Elderly

• Registration Number: NCT06986395
• Lead Sponsor: West China Hospital

Brief Summary

Brief Title: Safe Exercise for Age-Related Muscle Loss in Hospitalized Seniors

Summary:

This study compares two exercise methods to help older hospital patients (age 65+) rebuild muscle strength after being diagnosed with sarcopenia (age-related muscle loss). We want to know if using special pressure cuffs during light exercise works better than traditional strength training alone.

Who Can Join:

Hospitalized seniors with stable health conditions Excludes those with severe disabilities, dementia, or certain blood circulation problems

What We'll Do:

40 participants will be randomly assigned to either:

Traditional Training Group:

Uses weights/bands at 65-75% max capacity Arm/leg exercises 3x/week for 4 weeks

Pressure Cuff Training Group:

Uses special cuffs on arms/thighs during lighter exercises (20% max capacity) Same exercise frequency with controlled pressure for safety

What We'll Measure:

Handgrip strength (main test at 0/4/12 weeks) Walking speed, balance tests, quality of life surveys Any side effects like dizziness/nausea

Safety First:

Doctors will check your health before starting. Nurses will monitor every session. We use medical-grade cuffs with safe pressure limits (arm: 80-100mmHg, thigh: 150-200mmHg). You can stop anytime if uncomfortable.

Why This Matters:

This could help hospitalized seniors regain strength faster using gentler exercises. All activities are supervised by rehabilitation specialists at West China Hospital, with ethics committee approval (IRB number required).

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-01
• Study Start: 2025-05
• Study First Submitted: 2025-05-20
• Study First Submitted QC: 2025-05-20
• Last Update Submitted: 2025-05-20
• Study First Posted: 2025-05-23
• Last Update Posted: 2025-05-23
• Primary Completion: 2025-09-01
• Study Completion: 2025-09-10

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Hospitalized patients aged ≥65 years
• Diagnosed with sarcopenia per EWGSOP2019 criteria
• Acute medical conditions stabilized for ≥4 weeks (e.g., resolved infections, controlled heart failure)

Exclusion Criteria

• Severe disability (Barthel Index ≤40)

• Significant cognitive impairment (MMSE ≤18) or major psychiatric disorders (DSM-5 criteria)

• Contraindications to blood flow restriction training:

  • History/predisposition to deep vein thrombosis
  • Coagulopathy (INR >1.5, platelets <100×10⁹/L)
  • Symptomatic varicose veins (CEAP class C4-C6)
  • Uncontrolled hypertension (BP >160/100 mmHg)
  • Chronic lymphedema (ISL stage II-III)
  • Peripheral artery disease (ABI ≤0.7)
  • Active systemic infection (CRP >10 mg/L)
  • Malignancy (except non-melanoma skin cancer)
  • Severe renal impairment (eGFR <30 mL/min/1.73m²)
  • Acute coronary syndrome within 3 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in Handgrip Strength	Baseline (Week 0), Post-intervention (Week 4), Follow-up (Week 12)

Secondary Outcome Measures

Name	Time	Method
6-Meter Walking Speed	Baseline (Week 0), Follow-up (Week 12)
Short Physical Performance Battery (SPPB)	Baseline (Week 0), Post-intervention (Week 4), Follow-up (Week 12)
Timed Up and Go Test (TUG)	Baseline (Week 0), Post-intervention (Week 4), Follow-up (Week 12)
MBI	Baseline (Week 0), Post-intervention (Week 4), Follow-up (Week 12)