Study of neuroinflammation and aging of Alzheimer's dementia using multimodal neuroimaging (MRI and PET)

Recruiting

Conditions: Diseases of the nervous system

Registration Number: KCT0005431

Lead Sponsor: Gachon University Gil Medical Center

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 360

Inclusion Criteria

Cognitively Normal (CN) • Normal cognition will be defined
according to neuropsychological testing, which didn't fall within 1.5 SD,
and Clinical Dementia Rating (CDR) was 0 . - Mild cognitive impairment (MCI):
• CDR was 0.5 • Subjects were not be clinically diagnosed with dementia
according to Diagnostic and Statistical Manual of Mental Disorders, 4th.
Edition, Text-revision (DSM-IV-TR) criteria. - Dementia (AD) - Alzheimer's
disease (AD): • CDR = 0.5 • subjects were diagnosed with dementia according to
DSM-IV-TR. • subjects were diagnosed with probable AD or possible AD according
to the National Institute of Neurological and Communicative Disorders and Stroke
and the Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA)
criteria.

Exclusion Criteria

- Subjects who do not meet the inclusion criteria. -
Subjects who have history of any significant neurological disease other than AD
or VD , such as traumatic brain injury, Parkinson's disease,
Huntington's disease, motor neuron disease, or multiple sclerosis. -
Subjects who have history of brain tumor, normal presure hydrocephalus,
encephalitis, or metabolic encephalopathy. - Subjects who have history of a
massive stroke in cerebrum, brain strem or cerebellum. - Subjects who have
history of psychiatric disorder. - Subjects unable to undergo MRI or PET
scanning. - Pregnent or reast feeding women.

Study & Design

Study Type: Observational Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantitative,topographical analysis, and standardized uptake value <br>ratio (SUVR) map generation for 18F-Flutemetamol PET and 18F-DPA-714 <br>PET;Generation of the cortical cortical thickness map through <br>anatomical MRI;Generation of structural connectivity and fiber tractography <br>through Diffusion MRI;Generation of functional connectivity map through Resting-state <br>fMRI

Secondary Outcome Measures

Name	Time	Method
Comparison of cognitive function and brain structure changes <br>between groups during follow-up;Comparison of cognitive function and neuroinflammation between <br>groups during follow-up;Analysis of effect on cognitive impairment and brain atrophy during <br>follow-up