Rehabilitation for women with breast cancer undergoing ajduvant chemotherapy.
- Conditions
- Cancer
- Registration Number
- PACTR202007730554581
- Lead Sponsor
- APERE
- Brief Summary
Compared to controls, a significant increase in the WS (P < 0.01) and the WD (P < 0.01) accompanied by a significant decrease in resting rHR (P < 0.01), exercising HR6' (P < 0.01), [La]b (P < 0.05), HR6'/WS (P < 0.01) and [La]b/WS ratios (P < 0.01) was reported in the trained group. However, a significant decrease both in WD (P < 0.01) and WS (P < 0.01) has been observed in the controls. No significant difference was observed in resting HR, exercising HR6', [La]b, HR6'/WS, and [La]b/WS ratios were observed in the control group. A significant improvement was observed for RPE in training group (P < 0.05).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 39
Women aged from 18 to 65 years.
- No known history of chronic respiratory, cardiac or neuromuscular disease.
- Diagnosed with non-metastatic breast cancer (stage y–IIIA).
- Women who have had a mastectomy and are in the process of adjuvant chemotherapy (postoperative).
- Hemoglobin concentration < 8 g/dL, platelet count < 20/nL.
- Obesity [body mass index (BMI) > 30].
- Malnutrition (BMI < 20).
- Treatment with high-dose corticoids (prednisone > 50 mg/day or equivalent dose of related agents).
- Chronic infection, neurological or muscular impairment.
- chronic diseases that could be exacerbated by exercise (coronary artery disease, chronic obstructive pulmonary
disease, osteoarthritis), skeletal metastases resulting in bone instability, or progressive disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Compared to controls, we mentioned a positive effects of our training protocol on the aerobic fitness and metabolic needs of our trained patients. A significant increases in MViC, ET in an isometric test, and muscle deoxygenating ?HHb. In addition, we observed an improvement in the myoelectric activity of the Vastus lateralis, characterized by the decrease of the RMS and the increase of the MPF during the holding phase of 50% of the MViC, in the trained group after the six weeks combined aerobic training and muscle strengthening. Finally , we observed a significant improvement in the quality of life of the trained group. This improvement is characterized, on the one hand, by an increase in the overall quality of life and scores at the functional scales, and on the other hand by a reduction in the scores of symptom scales in cancer patients treated with adjuvant chemotherapy
- Secondary Outcome Measures
Name Time Method Concentration and rating of perceived exertion (RPE), Before and after six weeks of training program.