Evaluation of the Hemodynamic Repercussions of Non Invasive Ventilation in Healthy Individuals by Doppler Echocardiography
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Haemodynamic Rebound
- Sponsor
- Federal University of Uberlandia
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Hemodynamic repercussions of different levels of positive end expiratory pressure applied noninvasively, measured by echocardiography
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for safety and effectiveness of the technique application.
The main objective of this research is to evaluate the hemodynamic repercussions using doppler echocardiography in healthy volunteers submitted a different values of positive end expiratory pressure (PEEP) by the following ventilatory modes: Continuous positive airway pressure (CPAP) and Bilevel.
The study hypothesis is that the positive end expiratory pressure (PEEP) may cause hemodynamic repercussions as: reduction of the ventricles pre-load, left ventricle after load, cardiac output and reduction in the diameter of the superior vena cava, due to the increase in the intrathoracic pressure and pulmonary volumes.
Investigators
Gabrielle Silva Vinhal
Avaliação das repercussões hemodinâmicas com o uso de ventilação mecânica não invasiva em indivíduos saudáveis por meio do ecodopplercardiograma
Federal University of Uberlandia
Eligibility Criteria
Inclusion Criteria
- •Healthy individuals
- •Age between 18 and 40 years old
- •Non smoker
Exclusion Criteria
- •Clinical signs or symptoms of any disease decompensation
- •History of blood pressure variations by autonomic dysfunction
- •Sense of claustrophobia
Outcomes
Primary Outcomes
Hemodynamic repercussions of different levels of positive end expiratory pressure applied noninvasively, measured by echocardiography
Time Frame: 5 minutes
The hemodynamic variables evaluated are: ventricular preload, left ventricle afterload, cardiac output, blood pressure and the vena cava's diameter. All variables will be assessed by echocardiography
Secondary Outcomes
- Measurement of cardiac output as a predictor of cardiopulmonary adaptation to different pressures.(5 minutes)