Bone healing in dental patients
- Conditions
- Other and unspecified diseases ofpulp and periapical tissues, (2) ICD-10 Condition: K049||Other and unspecified diseases ofpulp and periapical tissues,
- Registration Number
- CTRI/2024/03/064064
- Lead Sponsor
- Tejas Suryawanshi
- Brief Summary
**Background:** Delayed Periapical healing is a common finding in treated root canals. Various additive and alterations have been tried in order to hasten the healing process in literature. Platelet concentrates have been studied in dentistry with satisfactory results but the clot like form of these concentrates was not in favour of Endodontist in closed apex cases due to consistency of the concentrates. Recently Injectable PRF (iPRF) is being used in dermatology, Orthopedics due to good amount of growth factors and liquid like consistency.
**Objectives:** To evaluate and compare the efficacy of A-PRF+ and i-PRF in periapical healing of patients with mature permanent teeth radiographically.
**Materials and Methods:** A total of 34 patients with Apical Periodontitis related to permanent central incisors will be included in the study. The Subjects will undergo conventional Access opening, Biomechanical preparation and irrigation. In control group (n=17) freshly made APRF+ will be pushed out of the root apex with help of pluggers. While in the intervention group (n=17) freshly made iPRF will be injected beyond the root apex. MTA barrier of 2 mm will be placed above it and the teeth will be sealed thermoplastically by Gutta percha in both the groups.
Intra Oral Periapical Radiographs will be taken T0 (on the day), T1 (6 months) T2 (12 months) to assess Periapical healing post operatively.
**Expected outcome:** iPRF is expected to outperform APRF+ in periapical healing because of the intricate and tapered form of Dental Root Canal Systems liquid consistency of the material may be favorable when compared to semisolid clot like consistency of APRF+.
**Keywords:** Periapical Bone healing, iPRF, APRF+, Apical Periodontitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 34
- Subjects Will have a mature, single-rooted, necrotic anterior tooth.
- The chosen individuals will be free of systemic illness and known allergic responses to any of the prescribed antibiotics.
- Individuals with peripheral vascular diseases, cancer, diabetes mellitus, and coronary artery disease.
- Those receiving long-term corticosteroid therapy.
- 3.Those who are immunocompromised.
- 4.Females who are expecting or nursing.
- 5.Those who have chronic widespread periodontitis.
- 6.Patients with teeth that cannot be restored.
- 7.Teeth that have undergone root canal therapy.
- 8.Teeth having abnormal development.
- 9.Internal and externally resorbing teeth.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy of iPRF & APRF in the management of patients with mature permanent teeth for periapical bone healing using an IOPA radiograph all the outcomes will be assessed on T0-on the day, T1 -6 months T2- 12 months with Intra oral peeriapicaal radiograph To evaluate the efficacy of APRF in the management of patients with mature permanent teeth for periapical bone healing using an IOPA radiograph all the outcomes will be assessed on T0-on the day, T1 -6 months T2- 12 months with Intra oral peeriapicaal radiograph To evaluate the efficacy of PRF in the management of patients with mature permanent teeth for periapical bone healing using an IOPA radiograph all the outcomes will be assessed on T0-on the day, T1 -6 months T2- 12 months with Intra oral peeriapicaal radiograph
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sharad pawar dental college and hospital wardha
🇮🇳Wardha, MAHARASHTRA, India
Sharad pawar dental college and hospital wardha🇮🇳Wardha, MAHARASHTRA, IndiaDr Tejas SuryawanshiPrincipal investigator7057380987tejassuryawanshi8997@gmail.com