Evaluation of Periapical Healing after Endodontic Microsurgery Using Different Retrograde Filling Materials With or Without Platelet Rich Fibrin - An In Vivo Study.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- The purpose of this study is the Evaluation of periapical healing of the lesion after an endodontic microsurgery with different retrograde filling materials, with or without Platelet Rich Fibrin (PRF) autologous material.
Study Overview
Brief Summary
The purpose of this study is the Evaluation of periapical healing of the lesion after an endodontic microsurgery with different retrograde filling materials, with or without Platelet Rich Fibrin (PRF) autologous material.
Total of 60 subjects with lesion not responding to conventional root canal treatment will be selected and endodontic microsurgery will be done. Retrograde root preparation will be done and subjects will be randomly divided into 4 groups of 15 members each based on the root end filling materials. Different retrograde filling materials(MTA, Biodentine) will be used with or without platelet rich fibrin.
wound healing will be evaluated radiographically by measuring the volume of the lesion using CBCT after 12 months post operation.
Study Design
- Study Type
- Interventional
- Allocation
- Coin toss, Lottery, toss of dice, shuffling cards etc
- Masking
- Participant and Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 25.00 Year(s) to 45.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1.Endodontic lesions not responding to conventional root canal treatments 2.Non-contributory medical history (ASA class I and class II) 3.Lesion involving 1-3 roots 4.Overfilled canals 5.Separated instrument in the apical half 6.Ledge formation or transportation in the canal 7.Anatomically complex root canal configurations.
Exclusion Criteria
- •1.Medically compromised patient (ASA class III to class VI) 2.Fractured tooth 3.Periodontally compromised patients 4.Through and through defects 5.Close Proximity to critical anatomical structures.
Outcomes
Primary Outcomes
The purpose of this study is the Evaluation of periapical healing of the lesion after an endodontic microsurgery with different retrograde filling materials, with or without Platelet Rich Fibrin (PRF) autologous material.
Time Frame: 1 week | 3 months | 6 months | 12 months
Secondary Outcomes
- The purpose of this study is the Evaluation of periapical healing of the lesion after an endodontic microsurgery with different retrograde filling materials, with or without Platelet Rich Fibrin(1 week)