Electrical Impedance Tomography: Collapse in Dependent Areas as a Predictor of Response to Prone Position Ventilation in COVID-19 Acute Respiratory Distress Syndrome

Completed

• Conditions: Acute Respiratory Distress Syndrome; SARS-CoV Infection

• Registration Number: NCT04603755
• Lead Sponsor: Direction Centrale du Service de Santé des Armées

Brief Summary

There are several clinical presentations of SARS-CoV-2 infection. Among the severe forms, pulmonary involvement with respiratory failure is common. Although severe lung involvement with SARS-CoV-2 meets the Berlin criteria for Acute Respiratory Distress Syndrome (ARDS), it differs from classic ARDS in that compliance (reflecting distensibility of the lung parenchyma) is frequently preserved.

If the interest of Electrical Impedance Tomography has been demonstrated in classical ARDS, this is not the case in ARDS with COVID-19.

However, the use of this technique in this particular patient population would make it possible to distinguish patients with severe hypoxemia linked to derecruitment from those without derecruitment, in whom hypoxemia is more likely to be linked to the loss of hypoxic vasoconstriction.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-10-24
• Study First Submitted QC: 2020-10-24
• Study Start: 2020-10-26
• Study First Posted: 2020-10-27
• Primary Completion: 2021-03-18
• Study Completion: 2021-03-18
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-14
• Last Update Posted: 2021-09-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients admitted to the intensive care unit for SARS-CoV-2 ARDS
• Under controlled invasive ventilation for less than 7 days

Exclusion Criteria

• Pneumothorax
• Deformation of the rib cage
• Contraindication to Electrical Impedance Tomography
• Pregnant or breastfeeding woman

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coefficient of correlation between the percentage of derecruitment of dependent areas (measured with Electrical Impedance Tomography) and the response to prone position	Up to 7 days	The percentage of derecruitment of dependent areas will be measured every day with Electrical Impedance Tomography.; The response to prone position will be assessed every day.

Trial Locations

Locations (2)

Hôpital d'Instruction des Armées Sainte-Anne; 🇫🇷 Toulon, France

Hôpital de la Timone; 🇫🇷 Marseille, France