Electrical Impedance Tomography Monitoring and Invasive Mechanical Ventilation During Pronation in Acute Respiratory Distress Syndrome.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ARDS, Human
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Pronation and Regions of Interest increase in percentage
- Last Updated
- 4 years ago
Overview
Brief Summary
Acute respiratory distress syndrome is an acute form of lung injury. The most commonly used classification criteria for this syndrome are Berlin's Criteria. The actual literature underlines the advantages of prone position in mild or severe forms of ARDS in association with invasive mechanical ventilation. The hypothesis of this study is to investigate the effective ventilation and perfusion modifications during pronation assessed with clinical parameters and with the aid of the electrical impedance tomography.
Investigators
Luigi Vetrugno
Clinical Professor in Anesthesiology and Intensive Care
Azienda Sanitaria-Universitaria Integrata di Udine
Eligibility Criteria
Inclusion Criteria
- •mild or severe ARDS according to Berlin's Criteria
- •recruitment maximum 72 hours from the diagnosis of ARDS
Exclusion Criteria
- •other non-ARDS respiratory system pathologies
- •hemodynamic instability (mean arterial pressure \< 60 mmHg)
- •pneumothorax
- •endocranial hypertension
- •skin lesions or burns
- •presence of pacemaker or implantable defibrillator
- •pregnancy
Outcomes
Primary Outcomes
Pronation and Regions of Interest increase in percentage
Time Frame: 1 hour after supination
Demonstrate that pronation, without any recruitment maneuver, augments the dorsal regions of interest of 5%.
Secondary Outcomes
- Region of Interest ratio and days of mechanical ventilation.(30 days after pronation)
- Region of Interest ratio and length of stay in intensive care unit(30 days after pronation)
- PaO2/FiO2 ratio and ventral/dorsal Regions of Interest ratio(1 hour after supination)
- Homogeneity of the ventral and dorsal regions from 0 to 1(1 hour after supination)