Electrical Impedance Tomography Monitoring and Invasive Mechanical Ventilation During Pronation in Acute Respiratory Distress Syndrome.
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Pronation and Regions of Interest increase in percentage
研究概览
简要总结
Acute respiratory distress syndrome is an acute form of lung injury. The most commonly used classification criteria for this syndrome are Berlin's Criteria. The actual literature underlines the advantages of prone position in mild or severe forms of ARDS in association with invasive mechanical ventilation. The hypothesis of this study is to investigate the effective ventilation and perfusion modifications during pronation assessed with clinical parameters and with the aid of the electrical impedance tomography.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •mild or severe ARDS according to Berlin's Criteria
- •recruitment maximum 72 hours from the diagnosis of ARDS
排除标准
- •other non-ARDS respiratory system pathologies
- •hemodynamic instability (mean arterial pressure < 60 mmHg)
- •pneumothorax
- •endocranial hypertension
- •skin lesions or burns
- •presence of pacemaker or implantable defibrillator
- •pregnancy
结局指标
主要结局
Pronation and Regions of Interest increase in percentage
时间窗: 1 hour after supination
Demonstrate that pronation, without any recruitment maneuver, augments the dorsal regions of interest of 5%.
次要结局
- Region of Interest ratio and days of mechanical ventilation.(30 days after pronation)
- Region of Interest ratio and length of stay in intensive care unit(30 days after pronation)
- PaO2/FiO2 ratio and ventral/dorsal Regions of Interest ratio(1 hour after supination)
- Homogeneity of the ventral and dorsal regions from 0 to 1(1 hour after supination)
研究者
Luigi Vetrugno
Clinical Professor in Anesthesiology and Intensive Care
Azienda Sanitaria-Universitaria Integrata di Udine