Impact of Fatty Stimuli on Cerebral Activity in Anorexia Nervosa: a Multi-sensory Approach
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Brain activity measured by functional MRI
研究概览
简要总结
Lipid restriction is significant in anorexia nervosa and limits therapeutic management. The multisensory perception of fat is altered, creating an aversion to lipids. The investigators aim to characterize the impact of sensory stimulation (smells or images) associated with specific tastes using neuropsychological assessments and functional MRI. Some volatile aromas can enhance the perception of the associated taste. The investigators hypothesize that such associations are altered in anorexia nervosa for fatty foods but may be preserved for sweet tastes, and that this alteration contributes to the maintenance of the disease. The interdependence of different sensory perceptions of lipids could play a major role in the therapeutic approach, aiding in the deconditioning of this aversion and the restoration of positive food sensory associations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Person affiliated or entitled to a social security scheme
- •Person having received informed information on the study and having co-signed, with the investigator, a consent to participate in the study
- •female person
- •Person affiliated or entitled to a social security scheme
- •Over 18 years'old
- •Knowing how to read and write French
- •Patient diagnosed with anorexia nervosa according to DSM-5 criteria for at least 5 years (HAS criteria). Failure of prior outpatient or/and hospitalization care over the last 12 months: stable or falling low BMI, unmodified food restriction, continued fear of weight gain, disturbances in the perception of body image
- •BMI < 18.5 kg/m² for volunteers in a state of constitutional thinness. The absence of eating disorder and the absence of restriction to DEBQ questionnaires. Fertility preserved.
- •For volunteers of normal weight: 18.5 kg/m² < BMI < 25 kg/m²
排除标准
- •Pregnant women, parturient, nursing mothers;
- •Persons deprived of their liberty, hospitalized without consent, hospitalized for purposes other than research;
- •Refusal of the study by the participant
- •Person incapable of giving informed consent
- •Artificial nutrition
- •Associated organic damage favoring undernutrition: other chronic diseases (digestive, infectious, endocrine, pulmonary, cardiac, neurological), neoplasms, etc.
- •Abuse of psychoactive substances except tobacco
- •Characterized depressive episode, psychosis
- •Score less than 14 on the Edinburgh laterality questionnaire.
- •Contraindications to MRI or allergy to one of the components of the olfactory and taste tests
- •Smell or taste alterations
研究组 & 干预措施
Low Weight Control group
30 control subjects with a similar weight to AN patients (the constitutional thinness group)
干预措施: Smell and taste capacity testings (Other)
Anorexia Nervosa patient group
30 patients with anorexia nervosa
干预措施: MRI examination (Other)
Normal Weight Control group
30 control subjects of normal weight
干预措施: MRI examination (Other)
Anorexia Nervosa patient group
30 patients with anorexia nervosa
干预措施: Smell and taste capacity testings (Other)
Normal Weight Control group
30 control subjects of normal weight
干预措施: Smell and taste capacity testings (Other)
Low Weight Control group
30 control subjects with a similar weight to AN patients (the constitutional thinness group)
干预措施: MRI examination (Other)
结局指标
主要结局
Brain activity measured by functional MRI
时间窗: Day 1
Estimation of the "fatty vs. neutral" contrast when all three senses are used, comparing AN patients to the normal-weight control group (NC group) in each voxel of the brain volume (whole-brain analysis) and in the orbitofrontal cortex (ROI analysis).
次要结局
- Brain activity measured by functional MRI(Day 1)
- BMI(DAY 1.)
- Olfactory and gustatory abilities(Day 1)
- 3DT1 morphological MRI(Day 1)