A randomised controlled trial in older adults with documented cognitive decline of computerised cognitive training compared to active control training on memory outcomes.

niversity of Sydney0 sites86 target enrollmentDecember 10, 2015

Overview

No summary available.

Registry

who.int

Start Date

December 10, 2015

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

•Older adults (aged 60 years or older) with documented longitudinal cognitive decline unresponsive to intervention (not attributable by illness or new medication onset): those individuals who, over the course of at least 6\-24 months and multiple neuropsychological assessments have had any memory\-related test decline by at least 0\.5SD of age\-corrected norms despite routine clinic intervention. Memory tests administered by the clinics include: WMS\-III Logical memory (I and II), the RAVLT and the Rey Complex Figure.

•(1\) history, diagnosis or treatment for dementia (of any aetiology); (2\) current use of third\-generation or tricyclic antidepressants; (3\) history of stroke in last 12 months; (4\) major neurological disorder requiring current treatment (epilepsy, Parkinson's disease); (5\) major psychiatric disorder requiring current treatment (schizophrenia, bipolar disorder); (6\) physical (sensory or motor) impairment that would limit training; (7\) current undertaking of any other computerised cognitive training (CCT) program; (8\) current alcohol dependence or abuse (defined as drinking over NHMRC guidelines); (9\) definitive exclusion of possible undiagnosed major depression using the Geriatric Depression Scale (15\-item score 10 or greater) or Hamilton Rating Scale for Depression (17\-item score 12 or greater) i.e. if participants were found to have clinical depression scores at baseline measurement that were not previously diagnosed, these participants will be excluded.