ACTRN12615001053516
Completed
未知
A Randomised Controlled Trial in older adults with mild cognitive or memory impairment, investigating the Cognitive Benefits of a Combined Flavonoid/Fatty Acid Intervention and Underlying Mechanisms of Action: The COGNITIVE AGING NUTRITION and NEUROGENESIS (CANN) Trial
Swinburne Univeristy0 sites240 target enrollmentOctober 7, 2015
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- Swinburne Univeristy
- Enrollment
- 240
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For main study:
- •Male and female, aged 55 years and over
- •Mild cognitive impairment (MCI) or subjective memory impairment (SMI) with no indication of clinical dementia or depression
- •Willing and able to provide written informed consent.
- •Understands and is willing and able to comply with all study procedures.
- •Fluent in written and spoken English.
- •In good general health including blood biochemical, haematological and urinalysis within the normal range at
- •screening (as judged by the clinical advisor)
- •Normal, or corrected to normal vision and hearing
- •Right handed, for MRI
Exclusion Criteria
- •Diagnosis of Alzheimer's disease (AD) or other form of dementia or significant neurological disorder
- •Parent or sibling who developed premature dementia \<60y (suggestive of a familial monogenic form of cognitive decline)
- •Past history or MRI evidence of brain damage including significant trauma, stroke, learning difficulties or serious neurological disorder, including loss of consciousness \> 24 hours
- •History of alcohol or drug dependency within the last 2 years
- •Other clinically diagnosed psychiatric disorder likely to affect the cognitive measures (as judged by clinical adviser)
- •Existing diagnosed gastrointestinal disorders likely to impact on absorption of flavonoids and fatty acids (as judged by clinical adviser)
- •Major cardiovascular event, e.g. myocardial infarction or stroke, in the last 12 months
- •Carotid stents or severe stenosis
- •Known allergy to fish or any other component in the intervention supplements
- •Existing medical conditions likely to affect the study measures (as judged by clinical adviser)
Outcomes
Primary Outcomes
Not specified
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