The effect of computerised cognitive training on memory outcomes in older adults with documented cognitive decline.

Not Applicable

Withdrawn

• Conditions: Secondary prevention of cognitive decline; Neurological - Dementias; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12615001347550
• Lead Sponsor: niversity of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-12-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

Older adults (aged 60 years or older) with documented longitudinal cognitive decline unresponsive to intervention (not attributable by illness or new medication onset): those individuals who, over the course of at least 6-24 months and multiple neuropsychological assessments have had any memory-related test decline by at least 0.5SD of age-corrected norms despite routine clinic intervention. Memory tests administered by the clinics include: WMS-III Logical memory (I and II), the RAVLT and the Rey Complex Figure.

Exclusion Criteria

(1) history, diagnosis or treatment for dementia (of any aetiology); (2) current use of third-generation or tricyclic antidepressants; (3) history of stroke in last 12 months; (4) major neurological disorder requiring current treatment (epilepsy, Parkinson's disease); (5) major psychiatric disorder requiring current treatment (schizophrenia, bipolar disorder); (6) physical (sensory or motor) impairment that would limit training; (7) current undertaking of any other computerised cognitive training (CCT) program; (8) current alcohol dependence or abuse (defined as drinking over NHMRC guidelines); (9) definitive exclusion of possible undiagnosed major depression using the Geriatric Depression Scale (15-item score 10 or greater) or Hamilton Rating Scale for Depression (17-item score 12 or greater) i.e. if participants were found to have clinical depression scores at baseline measurement that were not previously diagnosed, these participants will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The RAVLT: Ability to learn new information, assessed by the Sum of Trials 1-5 (total learning).[all time points: baseline, 3 months, 6 months, 18 months];The RAVLT: Trials 7 score will measure delayed recall ability in memory. [Baseline, 3, 6, and 18 months]