Diagnostics using perfusion CT imaging to determine the extent of bone marrow involvement of the mandible by squamous cell carcinoma - a pilot study
Completed
- Conditions
- oral canceroral cavity carcinoma10072990
- Registration Number
- NL-OMON35141
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Patients, 18 year of age or older, with a squamous cell carcinoma of the oral cavity or oropharynx, fixed to the mandible. Conventional X-ray imaging shows cortical or bonemarrow mandibular involvement.
Exclusion Criteria
Prior surgry in the head and neck region or cervicofacial radiotherapy. Mandibular osteomyelitis, recent tooth removal(s). Allergy for contrast agent. Severe kidney diseases.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Determine the extension of bone marrow involvement of the mandible by SCC.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Perfusion CT imaging can prevent unnecessary resection of the mandible.</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does perfusion CT imaging reveal in mandibular bone marrow involvement by squamous cell carcinoma?
How effective is perfusion CT compared to standard imaging techniques in assessing oral cancer bone marrow spread?
Are there specific biomarkers associated with mandibular bone marrow infiltration in oral cavity carcinoma?
What adverse events are linked to perfusion CT diagnostics in head and neck cancer patients and how are they managed?
What are the current therapeutic approaches for bone marrow involvement in squamous cell carcinoma of the oral cavity?