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Clinical Trials/NCT06242015
NCT06242015CompletedNot Applicable

The Effect of Ordered Eating on Postprandial Glucose and Substrate Utilization During an Acute Exercise Bout

Old Dominion University2 sites in 1 country23 target enrollmentStarted: February 6, 2024Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
23
Locations
2
Primary Endpoint
Postprandial glucose

Study Overview

Brief Summary

There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.

Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Basic Science
Masking
None

Eligibility Criteria

Ages
18 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
  • •Ability to perform moderate-to-high intensity running for at least 30 minutes

Exclusion Criteria

  • •Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
  • •Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
  • •Currently pregnant
  • •Implanted electrical devices such as a pacemaker.

Arms & Interventions

Carbohydrate-first meal

Experimental

Intervention: Carbohydrate-first meal (Other)

Carbohydrate-last meal

Experimental

Intervention: Carbohydrate-last meal (Other)

Outcomes

Primary Outcomes

Postprandial glucose

Time Frame: 2 hours (premeal and 30, 60, 90, and 120 minutes after eating)

Blood glucose will be measured with fingerstick samples and a portable glucometer

Secondary Outcomes

  • Hunger-satiety perceptions(2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating))
  • Carbohydrate use(100 minutes (premeal and continuously for 90 minutes after eating))
  • Fat use(100 minutes (premeal and continuously for 90 minutes after eating))
  • Rating of perceived exertion(30 minutes (at 8, 18, 28 minutes of exercise))

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Patrick Wilson, PhD

Associate Professor of Exercise Science

Old Dominion University

Study Sites (2)

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