Paracervical local anaethesia to mitigate post operative pain after total laparoscopic hysterectomy: A single centered, randomised, double-blinded, placebo-controlled, phase II study comparing the use of the paracervical block versus placebo.

St John of God Subiaco Hospital0 个研究点目标入组 94 人开始时间: 2021年5月17日最近更新: 2023年4月17日

试验速览

暂无简介。

•1.Women undergoing a total laparoscopic hysterectomy (TLH) plus or mimus bilateral
•Salpingo-oophorectomy (BSO) for any of the following conditions:
•a. Heavy menstrual bleeding/ abnormal uterine bleeding
•b. Stage 1 and 2 Endometriosis
•c. Adenomyosis
•d. Risk reduction surgery e.g. carriers of BRCA1/2 gene faults, Lynch Syndrome or
•women considered high risk due to family history
•e. Complex adnexal masses not suspicious for malignancy
•f. Early stage cervical cancer requiring simple hysterectomy
•2.Patients aged 18 years of age and over
•3.Fluent in English

•1.Chronic pelvic pain
•2.Recent opioid use (4 weeks prior to surgery)
•3.Deeply infiltrative endometriosis (evidence of nodular disease on USS) or endometrioma.
•4.Allergies to protocol drugs
•5.Endometrial cancer
•6.Patient requiring comprehensive surgical staging of malignant disease
•7.Previous midline laparotomy
•8.BMI >40kg/m2
•9.Renal impairment (eGFR< 60 or Cr > 100)
•10.Hepatic impairment (ALT> 40 or AST > 40)
•11.Alcohol and drug dependency
•12.Pregnancy

发起方

St John of God Subiaco Hospital