Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity. Influence of Low Respiratory Rate With Unchanged Minute Volume.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Gas change parameters
研究概览
简要总结
It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position. The investigators tried to investigate the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.
详细描述
Impaired gas exchange is a common anesthetic problem in obese subjects. It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEPi) is present in grossly obese subjects especially in the supine position. It is known that there is a significant negative correlation between PEEPi present and PaO2. Therefore, the investigators postulated that if the reduce the PEEPi by reducing the respiratory rate in obese subjects, the impaired gas exchange might improve.
The investigators tried to research the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Single (Care Provider)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA class I or II obesity, Body-mass index > 27.5 undergoing laparoscopic cholecystectomy
排除标准
- •patients with severe cardiopulmonary disease peak inspiratory pressure > 40 in the study setting
研究组 & 干预措施
RR 6 + 0
Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 0
干预措施: RR 6 + 0 (Device)
RR 10 + 0
Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 0
干预措施: RR 10 + 0 (Device)
RR 16 + 0
Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 0
干预措施: RR 16 + 0 (Device)
RR 6 + 5
Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 5
干预措施: RR 6 + 5 (Device)
RR 10 + 5
Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 5
干预措施: RR 10 + 5 (Device)
RR 16 + 5
Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 5
干预措施: RR 16 + 5 (Device)
结局指标
主要结局
Gas change parameters
时间窗: 15 minute interval
PaO2 and PaCO2 the result of arterial blood gas analysis
次要结局
- intrinsic positive end-expiratory pressure(every 15 minutes)
研究者
Won Ho Kim
Staff Anesthesiologist
Seoul Medical Center