Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity. Influence of Low Respiratory Rate With Unchanged Minute Volume.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- General Anesthesia
- Sponsor
- Seoul Medical Center
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Gas change parameters
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position. The investigators tried to investigate the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.
Detailed Description
Impaired gas exchange is a common anesthetic problem in obese subjects. It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEPi) is present in grossly obese subjects especially in the supine position. It is known that there is a significant negative correlation between PEEPi present and PaO2. Therefore, the investigators postulated that if the reduce the PEEPi by reducing the respiratory rate in obese subjects, the impaired gas exchange might improve. The investigators tried to research the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.
Investigators
Won Ho Kim
Staff Anesthesiologist
Seoul Medical Center
Eligibility Criteria
Inclusion Criteria
- •ASA class I or II obesity, Body-mass index \> 27.5 undergoing laparoscopic cholecystectomy
Exclusion Criteria
- •patients with severe cardiopulmonary disease peak inspiratory pressure \> 40 in the study setting
Outcomes
Primary Outcomes
Gas change parameters
Time Frame: 15 minute interval
PaO2 and PaCO2 the result of arterial blood gas analysis
Secondary Outcomes
- intrinsic positive end-expiratory pressure(every 15 minutes)