Effect of Individualized High Positive End-expiratory Pressure on Postoperative Pulmonary Rate in Laparoscopic Bariatric Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- postoperative pulmonary complication
研究概览
简要总结
Ventilation with low tidal volume and high PEEP (positive end expiratory pressure) has been shown to improve oxygenation in patients with ARDS (acute respiratory distress syndrome). In obese patients undergoing laparoscopic bariatric surgeries, the risk of postoperative pulmonary complications (PPCs) increases significantly with general anesthesia. Previous studies have shown that protective lung ventilation strategies could improve intraoperative oxygenation and lung mechanics.
In this study would compare the effect of optimum individualized high PEEP versus standard PEEP - on postoperative pulmonary complications
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients were eligible for participation if the met the following criteria
- •Age between 18 and 60 years old.
- •Body mass index > 40
- •Laparoscopic bariatric elective surgery under general anesthesia.
- •ARISCAT (Assess Respiratory Risk in Surgical Patients in Catalonia) score ≥ 45 . ARISCAT score is a clinically practical seven-factor scoring system to assess the risk of a composite PPC.
排除标准
- •Previous lung surgery
- •ASA status III or IV.
- •Moderate to severe obstructive or restrictive lung disease .
- •Persistant intraoperative hemodynamic instability .
- •Need for postoperative mechanical ventilation
结局指标
主要结局
postoperative pulmonary complication
时间窗: postoperative 10 days after surgery
pneumonia-atelactasis-bronchospasm-respiratory failure
次要结局
- Pulmonary functions test(postoperative 1st , 3rd and 5th day)