Quantitative Magnetic Resonance imaging modalities in the assessment and determination of PORTAL hypertension study

• Conditions: Increased portal pressure; 10019654; 10003184; 10057166

• Registration Number: NL-OMON56775
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Patients with liver disease:
• Patients of more than 18 years of age
• Written informed consent
• Patients with clinically proven portal hypertension due to chronic liver
disease, either moderate (history of oesophageal varices grade 2/3 without use
of beta-blockers as pharmaceutical treatment) or severe (recurrent oesophageal
variceal bleeding, therapy-resistant ascites)

Healthy controls:
• Patients of more than 18 years of age
• Written informed consent
• No known liver disease by means of liver function test/ultrasound

Exclusion Criteria

- Absolute contraindications to MR imaging
- Hepatocellular carcinoma or liver metastases

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• The diagnostic accuracy of TMRE for assessing portal hypertension severity.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Correlation of TMRE results (stiffness and viscosity) with HVPG pressure<br /><br>gradient measurements in patients with portal hypertension.<br /><br>• Correlation of TMRE results with US elastography measurements.<br /><br>• Correlation of TMRE results with ASL perfusion data.<br /><br>• Characterisation of TMRE in normalization of portal hypertension after<br /><br>medicinal or endovascular treatment.<br /><br>• The feasibility of novel synthetic MRI (SyMRI).</p><br>