The GFR-Exercise feasibility study

Not Applicable

• Conditions: Chronic kidney disease; Urological and Genital Diseases

• Registration Number: ISRCTN12609324
• Lead Sponsor: King's College Hospital NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-10-01
• Last Update Posted: 19 April 2021
• Study Completion: 2022-11-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1. Stages 3-4 CKD patients defined by the following criteria:
1.1. GFR 15-60mL/min from local lab CKD-EPI determined eGFR
1.2. Minimum decline= 5mL/min/year over previous 12-24 months, as meausured by linear regression analysis (minimum of 3 measurments of eGFR over 12 months)
2. Male or female
3. Age > 18 years
4. Declining CKD with no likelihood of reversibility

Exclusion Criteria

1. Age < 18 years
2. Pregnancy
3. Have a history of untoward reactions to iodinated contrast media
4. Have a recent history (last six months) episode of acute kidney injury or have sickle cell disease
5. Requires support for ambulation less than 20 meters
6. Psychosis, bi-polar, eating disorders, any other cognitive/neurological related issues
7. Infection or course of antibiotics within the last month
8. Enrolled in supervised exercise training in previous 3 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Feasibility:<br> 1. Number of participants screened per month, measured using a screening log monthly<br> 2. Number recruited per month, measured using an enrolment log monthly<br> 3. Proportions of eligible people unwilling to participate with reasons given (e.g. live too far away etc), measured using a screening log monthly<br> 4. Number retained per month, measured using an enrolment log monthly<br> 5. Proportion of planned data collection visits that are completed in full length of time for study visits<br> 6. Adherence to planned supervised exercise training schedule (number of sessions attended) of >80%, measured using Trust Database (PiMS) Clinic Attendance Log<br> 7. Completion of unsupervised exercise diaries of >80%<br>