Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men
Phase 4
Completed
- Conditions
- Sexual DysfunctionQuality of LifeInflammationEndothelial Dysfunction
- Registration Number
- NCT01642576
- Lead Sponsor
- Changi General Hospital
- Brief Summary
This study aims to compare the effects of 8 months of diet modification, with or without exercise, on weight loss, sexual, urinary and endothelial function, systemic inflammation and quality of life in obese men.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 90
Inclusion Criteria
- Male, aged 30-65 years
- Body Mass Index (BMI) >/= 27.5 kg/m2
- Waist circumference (WC) >/= 90 cm
Exclusion Criteria
- pituitary disease or cranial radiotherapy
- previous or current androgen replacement or deprivation therapy
- current treatment for sexual problems or LUTS
- glomerular filtration rate < 60 ml/min
- liver disease
- alcohol intake exceeding 500 g/week in the previous 12 months
- use of opiates, glucocorticoids, recreational drugs or phosphodiesterase inhibitors
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method erectile function 8 months IIEF-5 score
- Secondary Outcome Measures
Name Time Method lower urinary tract symptoms 8 months IPSS score
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link weight loss to improved endothelial function in obese men?
How does dietary intervention compare to standard-of-care treatments for sexual dysfunction in obesity?
Which biomarkers predict response to combined diet and exercise in reducing systemic inflammation?
What are the potential adverse events associated with long-term weight loss counseling in clinical practice?
Are there synergistic effects of combining dietary counseling with exercise on urinary function and quality of life in obese men?
Trial Locations
- Locations (1)
Changi General Hospital
🇸🇬Singapore, Singapore
Changi General Hospital🇸🇬Singapore, Singapore