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Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men

Phase 4
Completed
Conditions
Sexual Dysfunction
Quality of Life
Inflammation
Endothelial Dysfunction
Registration Number
NCT01642576
Lead Sponsor
Changi General Hospital
Brief Summary

This study aims to compare the effects of 8 months of diet modification, with or without exercise, on weight loss, sexual, urinary and endothelial function, systemic inflammation and quality of life in obese men.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
Male
Target Recruitment
90
Inclusion Criteria
  • Male, aged 30-65 years
  • Body Mass Index (BMI) >/= 27.5 kg/m2
  • Waist circumference (WC) >/= 90 cm
Exclusion Criteria
  • pituitary disease or cranial radiotherapy
  • previous or current androgen replacement or deprivation therapy
  • current treatment for sexual problems or LUTS
  • glomerular filtration rate < 60 ml/min
  • liver disease
  • alcohol intake exceeding 500 g/week in the previous 12 months
  • use of opiates, glucocorticoids, recreational drugs or phosphodiesterase inhibitors

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
erectile function8 months

IIEF-5 score

Secondary Outcome Measures
NameTimeMethod
lower urinary tract symptoms8 months

IPSS score

Trial Locations

Locations (1)

Changi General Hospital

🇸🇬

Singapore, Singapore

Changi General Hospital
🇸🇬Singapore, Singapore

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