Impact of Diet and/or Exercise-induced Weight Loss on Cardiovascular Risk Factors
Not Applicable
Completed
- Conditions
- Cardiovascular Diseases
- Registration Number
- NCT00588978
- Lead Sponsor
- Yale University
- Brief Summary
The purpose of this pilot study is to examine the effect of diet and/or exercise-induced weight loss on nontraditional cardiovascular risk factors such as c-reactive protein, insulin levels and sex steroids in obese postmenopausal women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 30
Inclusion Criteria
- obese postmenopausal women
- able to exercise
- non-smokers
Exclusion Criteria
- cardiovascular disease
- medications that would interfere with outcome measures (e.g., including ACE inhibitors, lipid lowering medications, beta-blockers, etc)
- known diabetes
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method c-reactive protein baseline, every 1-2 weeks during intervention , then end-of-study
- Secondary Outcome Measures
Name Time Method HOMA (measure of insulin resistance) and sex steroids baseline, every 1-2 weeks during intervention, then end-of-study
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link weight loss to reduced c-reactive protein in postmenopausal women with cardiovascular disease?
How does diet-induced weight loss compare to exercise-induced weight loss in improving insulin sensitivity among obese postmenopausal women?
Which nontraditional biomarkers like sex steroids are most predictive of cardiovascular risk reduction in postmenopausal women undergoing weight loss interventions?
What are the potential adverse events associated with behavioral interventions for weight loss in postmenopausal women with cardiovascular risk factors?
Are there combination approaches involving diet, exercise, and pharmacological agents that enhance cardiovascular risk factor reduction in obese postmenopausal women?
Trial Locations
- Locations (1)
Yale Center for Clinical Investigation
🇺🇸New Haven, Connecticut, United States
Yale Center for Clinical Investigation🇺🇸New Haven, Connecticut, United States