A randomised clinical trial examining the outcome of immediate versus early (24 to 48 hours) percutaneous coronary intervention in patients with an acute coronary syndrome without persistent ST-segment elevation

Amsterdam Department of Interventional Cardiology (ADIC) (Netherlands)0 个研究点目标入组 600 人开始时间: 2006年1月27日最近更新: 2015年1月13日

试验速览

暂无简介。

•1. Aged greater than 21 years
•2. Typical chest pain for angina pectoris lasting at least 10 minutes, within last 6 hours
•3. No contra-indication to PCI
•And at least one of the following criteria:
•4. 1 mm of horizontal or downsloping ST depression
•5. Dynamic ST- or T-wave changes greater than 1 mm in two contiguous leads
•6. Elevated troponin or creatine kiase myocardial bands (CK-MB)
•7. Known coronary artery disease
•8. Two of following risk factors: diabetes mellitus (DM), known hypertension, current smoking, family hx, hypercholesterolaemia, peripheral artery disease, age over 60 years

•1. Chest pain suspected not to be caused by coronary artery disease (CAD)
•2. Acute myocardial infarction requiring reperfusion therapy
•3. Thrombolytic therapy less than 24 hours/indication for thrombolytic therapy
•4. Recent PCI (less than 14 days)
•5. Thrombopaenia (less than 100 x 10^12/mm3)
•6. Severe bleeding less than 6 weeks
•7. Major surgery less than 6 weeks
•8. Cerebral haemorrhage in medical history
•9. High blood pressure left untreated (diastolic greater than 100 mmHg, systolic greater than 180 mmHg)
•10. Life expectancy less than 1 year due to co-morbidity
•11. Known intracranial malformation or neoplasm
•12. Participation in other study possibly interfering with the endpoints
•13. Inability to follow up
•14. Culprit lesion is a restenotic lesion

发起方

Amsterdam Department of Interventional Cardiology (ADIC) (Netherlands)