Optimal timing of coronary intervention in unstable angina

Completed

• Conditions: on ST-Elevation Acute Coronary Syndrome (NSTE-ACS); Circulatory System; Other acute ischaemic heart diseases

• Registration Number: ISRCTN80874637
• Lead Sponsor: Amsterdam Department of Interventional Cardiology (ADIC) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

1. Aged greater than 21 years
2. Typical chest pain for angina pectoris lasting at least 10 minutes, within last 6 hours
3. No contra-indication to PCI

And at least one of the following criteria:
4. 1 mm of horizontal or downsloping ST depression
5. Dynamic ST- or T-wave changes greater than 1 mm in two contiguous leads
6. Elevated troponin or creatine kiase myocardial bands (CK-MB)
7. Known coronary artery disease
8. Two of following risk factors: diabetes mellitus (DM), known hypertension, current smoking, family hx, hypercholesterolaemia, peripheral artery disease, age over 60 years

Exclusion Criteria

1. Chest pain suspected not to be caused by coronary artery disease (CAD)
2. Acute myocardial infarction requiring reperfusion therapy
3. Thrombolytic therapy less than 24 hours/indication for thrombolytic therapy
4. Recent PCI (less than 14 days)
5. Thrombopaenia (less than 100 x 10^12/mm3)
6. Severe bleeding less than 6 weeks
7. Major surgery less than 6 weeks
8. Cerebral haemorrhage in medical history
9. High blood pressure left untreated (diastolic greater than 100 mmHg, systolic greater than 180 mmHg)
10. Life expectancy less than 1 year due to co-morbidity
11. Known intracranial malformation or neoplasm
12. Participation in other study possibly interfering with the endpoints
13. Inability to follow up
14. Culprit lesion is a restenotic lesion

Study & Design

• Study Type: Interventional
• Study Design: Not specified