The Research of the Effect of Sevoflurane on Brain-protection of Cardiac Surgery in Infants.
Not Applicable
- Conditions
- Congenital Heart DiseaseInfant, Premature, Diseases
- Interventions
- Registration Number
- NCT03366597
- Lead Sponsor
- Jun Ma
- Brief Summary
To observe the effect of sevoflurane on the concentration of S100β and regional cerebral oxygen saturation in infants with congenital heart disease undergoing cardiac surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Clinical diagnosis of congenital heart disease
- Undergoing heart surgery with cardiopulmonary bypass
Exclusion Criteria
- Pulmonary arterial hypertension
- Sevoflurane allergy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Sevoflurane Sevoflurane Sevoflurane will be used as a narcotic drug in one group during cardiac surgery.
- Primary Outcome Measures
Name Time Method Concentration of S100β protein 5 minutes after tracheal intubation; immediately after cardiopulmonary bypass; immediately after operation; 12 hours, 24 hours postoperative The concentration of S100β protein was performed using the electrochemiluminescence immunoassay.(Blood samples from patients were drawn from central intravenous.)
- Secondary Outcome Measures
Name Time Method Level of regional cerebral oxygen saturation(rScO2) 5 minutes after tracheal intubation; immediately after cardiopulmonary bypass; immediately after operation; 12 hours, 24 hours postoperative The rScO2 was measured by using noninvasive near-infrared spectroscopy during cardiac surgery
Trial Locations
- Locations (1)
Beijing Anzhen Hospital
🇨🇳Beijing, Beijing, China