The effect of acupuncture pretreatment on the clinical pregnancy rate of IVF-ET in patients with diminished ovarian reserve: a multicenter randomized controlled trial

Not Applicable

Not yet recruiting

• Conditions: diminished ovarian reserve

• Registration Number: ITMCTR2024000021
• Lead Sponsor: Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-03-04

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

(1) Meets the criteria for Group 3 and Group 4 of the POSEIDON POR classification criteria;
(2) Female, 20 years = age < 40 years;
(3) Regular menstruation (21-35 days);
(4) Fertility needs, with a proposed IVF/ICSI-ET antagonist or microstimulation regimen to assist conception, and with a proposed transfer of 1-2 high-quality embryos at the cleavage stage or 1 blastocyst;
(5) Voluntarily participate in the trial and sign the informed consent form.

Exclusion Criteria

(1) FSH = 25 IU/L;
(2) Diseases related to the reproductive physician's judgment that affect conception (any of the following may be excluded if they do not affect embryo transfer): congenital abnormalities in the development of reproductive organs, untreated endometrial polyps, untreated uterine adhesions, untreated uterine infections, untreated tubal hydrosalpinx, thin endometrium, uterine fibroids (>5 cm, submucosal uterine fibroids), endometriosis, or other organic diseases;
(3) Repeated implantation failures (after at least 3 transfer cycles, fresh or frozen embryo transfer cycles involving the transfer of at least 4 high-quality embryos without pregnancy; or 2 consecutive fresh or frozen transfer cycles and the transfer of at least 4 cleavage-stage embryos or at least 2 high-quality blastocysts without obtaining a clinical pregnancy);
(4) Combination of metabolic endocrine diseases such as uncorrected hyperprolactinemia, hyperandrogenemia, thyroid dysfunction, chronic hypoadrenocorticism, or other metabolic endocrine diseases;
(5) Azoospermia in the male partner;
(6) Those with combined serious cardiovascular, cerebrovascular, hepatic, renal, malignant tumor, hematopoietic system and mental diseases;
(7) Those who have a history of acupuncture treatment;
(8) Recurrent abortion (refers to 2 or more consecutive pregnancy losses with the same spouse that occurred before 28 weeks of gestation, including biochemical pregnancy);
(9) Patients with severe anxiety, i.e., those with a score of >70 on the Self-Rating Anxiety Scale (SAS);
(10) Chromosomal abnormalities and carriers.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified