Effects of stearidonic acid on serum triacylglycerol concentrations in overweight and obese subjects
- Conditions
- 10013317hypertriglyceridemia / increased serum triacylglycerol concentrations
- Registration Number
- NL-OMON36066
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 36
- aged between 18-70 years
- Quetelet-index between 25-35 kg/m2
- mean serum triacylglycerol < 3.0 mmol/L
- unstable body weight (weight gain or loss >2 kg in the past 3 months)
- indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus
- use of medication or a diet known to affect serum lipid or glucose metabolism
- active cardiovascular disease like congestive heart failure or recent (<6 months) event (acute myocardial infarction, cerebro vascular accident)
- severe medical conditions that might interfere with the study such as epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel diseases and rheumatoid arthritis
- abuse of drugs
- more than 21 alcohol consumptions per week for men and 14 consumptions for women
- not or difficult to venipuncture as evidenced during the screening visits
- use of an investigational product within the previous 30 days
- not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in plant stanol or sterol esters 3 weeks before the start of the study
- not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study and during the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study parameters/endpoints: The main study parameter is the change is<br /><br>fasting serum triacylglycerol concentrations. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary endpoint is the change in the omega-3 index.</p><br>