Effects of dietary fat structure on short term changes in blood lipids and insulin sensitivity

Completed

• Conditions: Diet and cardiovascular disease; Circulatory System; Complications and ill-defined descriptions of heart disease

• Registration Number: ISRCTN20774126
• Lead Sponsor: King's College London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-03-13
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Healthy males and females, aged 18 - 45 years.

Exclusion Criteria

1. A reported history of heart disease, diabetes, cancer, kidney, liver or bowel disease (healthy volunteers are required)
2. Current cigarette smoker
3. History of substance abuse or alcoholism (previous weekly alcohol intake greater than 60 units/men or 50 units/women)
4. Current self-reported weekly alcohol intake exceeding 28 units
5. Unwilling to follow the protocol and/or give informed consent
6. Weight change of greater than 3 kg in preceding 2 months
7. Body mass index (BMI) less than 20 and greater than 35 kg/m^2
8. Blood pressure greater than 160/90 mmHg
9. Fasting blood cholesterol greater than 7.8 mmol/l, fasting plasma triacylglycerol concentrations greater than 3 mmol/l, or fasting plasma glucose greater than 7 mmol/L
10. Presence of gastrointestinal disorder or use of a drug, which is likely to alter gastrointestinal motility or nutrient absorption
11. Greater than or equal to 20% 10-year risk of cardiovascular disease (CVD) as calculated using the risk calculator
12. Vegetarian dietary practices
13. Pregnant women

Study & Design

• Study Type: Interventional
• Study Design: Not specified