The effect of subcutaneous glyceryl trinitrate on radial artery diameter and the utility in radial access coronary angiography

Not Applicable

Recruiting

• Conditions: Coronary artery disease; Coronary angiography; Transradial artery access; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12622000043730
• Lead Sponsor: Royal Brisbane & Women's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-01-17
• Last Update Posted: 15 August 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Patient attending for a planned coronary angiogram – outpatient or inpatient
Planned for transradial approach

Exclusion Criteria

Presentation requiring emergent coronary angiography including ST-elevation myocardial infarction (STEMI)
Cardiogenic shock
Requiring inotropic support or intra-aortic balloon pump insertion
Known severe aortic stenosis
Known left ventricular outflow tract obstruction (including hypertrophic cardiomyopathy)
No transthoracic echocardiogram in the month prior to procedure
Systolic blood pressure <90mmHg at the time of the procedure
Previous intolerance or reaction to glyceryl trinitrate
Known history of glaucoma or stroke or significant head trauma
Phosphodiesterase inhibitor (e.g. Sildenafil / Tadalafil) use in the preceding 4 days
Have been on regular long-acting nitrates in the previous 48 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Radial artery diameter measured using ultrasound at site of subcutaneous injection[Measurement of radial artery pre-injection and 1 minute post injection measured using a stopwatch];Time from first puncture to successful arterial sheath insertion measured using a stopwatch[At the time of successful arterial sheath insertion ];Radial artery diameter measured using ultrasound at opposite site to that of subcutaneous injection[Measurement of radial artery pre-injection and 1 minute post injection measured using a stopwatch]

Secondary Outcome Measures

Name	Time	Method
Total number of forward passes of the needle during radial artery puncture as assessed by operator self-report[At the time of successful arterial sheath insertion];Participant satisfaction as assessed by a pain score with a Visual Analogue Scale (VAS)[Assessed post completion of coronary angiogram];Rate of conversion to transfemoral access for completion of coronary angiogram as reported by the operator and documented in the procedure report [At the time of successful completion of coronary angiogram];Incidence of adverse affects associated with the use of subcutaneous glyceryl trinitrate (GTN) as reported in the patient medical record[At the time of completion of coronary angiogram]