Renal Failure Following Lung Transplantation in Cystic Fibrosis Patients

Completed

• Conditions: Cystic Fibrosis

• Registration Number: NCT05001841
• Lead Sponsor: Policlinico Hospital

Brief Summary

With this retrospective observational cohort study, we performed a longitudinal assessment of the renal function of the adult CF patients who underwent LUTX, aiming 1) to describe possible risk factors associated with perioperative AKI and 2) to describe AKI short and long term effects on clinical outcomes.

Detailed Description

This study is a retrospective analysis of prospectively collected data from medical records of all consecutive CF patients who underwent LUTX at our Institution from January 2013 to December 2018.

Study Timeline

• Study Start: 2013-01-01
• Primary Completion: 2018-12-31
• Study Completion: 2021-05-31
• Study First Submitted: 2021-07-24
• Status Verified: 2021-08
• Study First Submitted QC: 2021-08-03
• Last Update Submitted: 2021-08-03
• Study First Posted: 2021-08-12
• Last Update Posted: 2021-08-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 85

Inclusion Criteria

• All patients with CF who underwent LUTX during the study period were considered.

Exclusion Criteria

• single LUTX
• re-transplantation
• missing medical records;
• age < 18 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute Kidney Injury	1 month	AKI stage 1, stage 2, and stage 3 whether a 1.5-1.9 times, 2-2.9 times, and \>3 times increase from the preoperative creatinine was measured, respectively. Following KIDGO criteria

Secondary Outcome Measures

Name	Time	Method
Survival	Until May 31 2021	Death at follow-up

Trial Locations

Locations (1)

Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico; 🇮🇹 Milan, Italy