Postoperative Kidney Functions in Geriatric Major Gynecologic-Oncologic Surgery

• Conditions: Geriatrics; Acute Renal Injury; Gynecologic Surgery

• Registration Number: NCT05308810
• Lead Sponsor: Ankara City Hospital Bilkent

Brief Summary

The increasing number of patients who develop perioperative acute kidney injury (AKI) is partly related to the aging population and the increasing number of individuals with chronic comorbidities, particularly those with premorbid chronic kidney disease. Anesthesiologists and surgeons will increasingly have to deal with such patients who are elderly and have comorbidities and require major surgery.

The aim of this study was to determine the incidence of postoperative acute kidney injury (primary aim) in patients aged 65 and over who underwent elective major gynecological-oncological surgery under general anesthesia in Ankara City Hospital Gynecology-Oncology Operating Room between January 2020-2022 and were followed up in the PACU in the postoperative period. To investigate risk factors and their results in a retrospective manner in line with the KDIGO criteria (secondary purpose).

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-03
• Study First Submitted: 2022-03-18
• Study Start: 2022-04
• Study First Submitted QC: 2022-04-01
• Last Update Submitted: 2022-04-01
• Study First Posted: 2022-04-04
• Last Update Posted: 2022-04-04
• Primary Completion: 2022-06
• Study Completion: 2022-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

• patients underwent major abdominal gynecologic oncologic surgery between January 2021 and January 2022
• followed in the PACU

Exclusion Criteria

• Patients with inaccessible data and missing data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the incidence of the patients with AKI stage 2	48 hours after surgery	AKI STAGE 1 : increase Cr ≥ 0.3 mg/dl or increase Cr to 1.5-1.9 times from baseline; or urine volume \< 0.5 ml/kg/h for 6-12 hours; AKI STAGE 2 : increase to 2-2.9 times from baseline; or urine volume \< 0.5 ml/kg/h for ≥ 12 hours; AKI STAGE 3 : increase Cr to ≥ 3 times from baseline; or increase Cr ≥ 4 mg/dl or initiation of renal replacement therapy or decrease in GFR to \<35mL/min/1.73 m2 or urine volume \< 0.3 ml/kg/h for ≥ 24 hours or Anuria for ≥ 12 hours
the incidence of the patients with AKI stage 3	48 hours after surgery	AKI STAGE 1 : increase Cr ≥ 0.3 mg/dl or increase Cr to 1.5-1.9 times from baseline; or urine volume \< 0.5 ml/kg/h for 6-12 hours; AKI STAGE 2 : increase to 2-2.9 times from baseline; or urine volume \< 0.5 ml/kg/h for ≥ 12 hours; AKI STAGE 3 : increase Cr to ≥ 3 times from baseline; or increase Cr ≥ 4 mg/dl or initiation of renal replacement therapy or decrease in GFR to \<35mL/min/1.73 m2 or urine volume \< 0.3 ml/kg/h for ≥ 24 hours or Anuria for ≥ 12 hours
the incidence of the patients with AKI STAGE 1	48 hours after surgery	AKI STAGE 1 : increase Cr ≥ 0.3 mg/dl or increase Cr to 1.5-1.9 times from baseline; or urine volume \< 0.5 ml/kg/h for 6-12 hours; AKI STAGE 2 : increase to 2-2.9 times from baseline; or urine volume \< 0.5 ml/kg/h for ≥ 12 hours; AKI STAGE 3 : increase Cr to ≥ 3 times from baseline; or increase Cr ≥ 4 mg/dl or initiation of renal replacement therapy or decrease in GFR to \<35mL/min/1.73 m2 or urine volume \< 0.3 ml/kg/h for ≥ 24 hours or Anuria for ≥ 12 hours

Trial Locations

Locations (1)

Ankara City Hospital; 🇹🇷 Ankara, Turkey