The effect of single tablet of fixed-dose amlodipine and atorvastatin on blood pressure, lipid profile, and oxidative stress of the patients with type 2 diabetes mellitus
Not Applicable
- Conditions
- type 2 diabetes mellitus hypertension dyslipidemia
- Registration Number
- JPRN-UMIN000004924
- Lead Sponsor
- Department of Internal Medicine, School of Medicine, Keio University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
(1)mild to severe renal dysfunction(CKD stage 3 or more advanced, diabetic nephropathy 3B or more advanced) (2)allergy to amlodipine or atorvastatin (3)liver dysfunciton (acute hepatitis, acute deterioration of chronic hepatitis, liver cirhosis, hepatic cell carcinoma, jaundice) (4)(possible) pregnant woman, breast- feeding woman
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The blood pressure-lowering effect, the lipid profile-improving effect, and the effect to the MDA-LDL cholestreol of single tablet of fixed dose of amlodipine (5 mg) and atorvastatin (10 mg)
- Secondary Outcome Measures
Name Time Method eGFR, urinary albumin excretion Intima-Media Thickness Pulse Wave Velocity Questionnaire about medication adherance