The Modulatory Effects of Oxytocin and Vasopressin on Delta-beta Cross-frequency Coupling
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Resting-state EEG
研究概览
简要总结
The main aim of the study is to investigate whether intranasal oxytocin and vasopressin have effects on delta-beta cross-frequency coupling under resting-state and task conditions.
详细描述
A double-blinded, placebo-controlled, between-subject design is employed in this study. In a randomized order, a total of 120 healthy males and females are instructed to self-administer intranasal spray of oxytocin, vasopressin, or placebo. (1) 15-minute resting-state EEG data are collected 35 minutes after treatment. (2) Participants complete tasks including Stroop, GO/NOGO, and anxiety induction with behavioral (response time, accuracy, or rating) and EEG data being collected. Personality traits of subjects are assessed using validated Chinese version questionnaires including the Beck Depression Inventory (BDI-II), State-Trait Anxiety Inventory (STAI), Autism Spectrum Quotient (ASQ), and Adult ADHD Self-Report Scale (ASRS-v1.1). Participants are asked to complete Positive and Negative Affect Schedule (PANAS) when they just arrive, before resting state and after the tasks. Three blood samples (5 ml) are collected into 6 ml ETDA tubes when participants just arrive, before resting state recording and after all of the tasks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without past or current psychiatric or neurological disorders.
排除标准
- •History of head injury.
- •Pregnant,menstruating,taking oral contraceptives.
- •Medical or psychiatric illness.
研究组 & 干预措施
vasopressin
A single dose of 20 international units (IU) of vasopressin will be administered with 3 puffs of treatment to each nostril.
干预措施: Intranasal Vasopressin (AVP) (Drug)
oxytocin
A single dose of 24 international units (IU) of oxytocin will be administered with 3 puffs of treatment to each nostril.
干预措施: Intranasal Oxytocin (IN-OXT) (Drug)
placebo
A single dose of placebo will be administered with 3 puffs of treatment to each nostril.
干预措施: Intranasal Placebo (Drug)
结局指标
主要结局
Resting-state EEG
时间窗: 35-50 minutes after treatment administration.
Participants are asked to sit comfortably and look at a white cross fixation against a black background on the computer monitor for 15 minutes with delta-beta cross-frequency coupling as a main index.
Behavioral indices in the tasks
时间窗: 50-90 minutes after treatment administration.
Reaction time and accuracy are recorded in the emotional Stroop and Go/Nogo tasks. For the anxiety induction task, participants are instructed to rate their anxiety levels using a 9-point Likert scale within 4 seconds (1 = not at all, 9 = very anxious).
Task-based EEG
时间窗: 50-90 minutes after treatment administration.
EEG data are recorded in the emotional Stroop, Go/Nogo, and anxiety induction tasks. Delta-beta cross-frequency coupling will be calculated to do statistical analyses.
次要结局
- SCR in anxiety induction(70-90 minutes after treatment administration.)
研究者
Shuxia Yao
Associate Professor
University of Electronic Science and Technology of China