Effects of Intranasal Oxytocin and Vasopressin on Social Behavior in Healthy Controls

Hadassah Medical Organization1 site in 1 country150 target enrollmentApril 2011

ConditionsHealthy

InterventionsArginine Vasopressin Oxytocin placebo

DrugsOxytocin Arginine Vasopressin placebo

Overview

Phase: Not Applicable
Intervention: Arginine Vasopressin
Conditions: Healthy
Sponsor: Hadassah Medical Organization
Enrollment: 150
Locations: 1
Primary Endpoint: allocations of monetary units
Last Updated: 15 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to investigate the role of a one-time intranasal administration of the oxytocin, vasopressin, or placebo on prosocial decision making such as cooperation and altruism in a healthy population of student controls.

Registry

clinicaltrials.gov

Start Date

April 2011

End Date

May 2012

Last Updated

15 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Hadassah Medical Organization

Eligibility Criteria

Inclusion Criteria

•healthy controls

Exclusion Criteria

•Past or present psychiatric, neurological, endocrinological or severe chronic medical illness.
•Use of medications or drugs that would interfere with study results. This includes steroids, medications for psychiatric symptoms like anxiety or depression, stimulants, and medications for high blood pressure. Participants will be asked to tell the investigators of any medications or drugs that they are taking. The investigators will consider the drug interactions with oxytocin and vasopressin prior to study, and participants will not be able to participate in the study if the drug interactions could be dangerous.
•history of drug or alcohol addiction
•Pregnancy or Nursing Status: Because of the risk to an unborn fetus or infant, women who are pregnant or nursing are excluded from this protocol. All females will have a pregnancy test performed no more than 24 hours before each drug administration and will not be able to participate if the pregnancy test is positive.

Arms & Interventions

Vasopressin

vasopressin condition

Intervention: Arginine Vasopressin

oxytocin

oxytocin condition (syntocinon)

Intervention: Oxytocin

placebo

Intervention: placebo

Outcomes

Primary Outcomes

allocations of monetary units

Time Frame: approximately 45 minutes after intranasal administration of vasopressin, oxytocin, or placebo

Participants will make decisions regarding the allocation of monetary units between themselves and other participants. We will measure the quantity of monetary units kept for themselves vs. given to other participants