Effect of Amlodipine and Clomid on Blood Flow of Preovulatory Follicle in Polycystic Ovarian Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 主要终点
- change in ovarian artery perfusion
研究概览
简要总结
On the basis of the current study, amlodipine seems to be a promising drug on improving uterine, ovarian blood flow, size of pre-ovulatory follicle, midluteal progesterone level and pregnancy outcome in patients with pco.
详细描述
To know if amlodipine has vasodilator effect on ovarian ar. In pco patient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Demographic features including females in age of ≥20 & ≤35, and BMI of ≤
- •Infertility secondary to polycystic ovary , The choice of polycystic ovary patients will be according to the Rotterdam consensus workshop (Rotterdam, 2004), and the diagnosis of polycystic ovary by ultrasonography will be made according to Adams et al. criteria which are the most often cited (Adams et al., 1985).The Rotterdam criteria as follows:
- •Oligo- or anovulation.
- •Clinical and/or biochemical signs of hyper androgynism
- •The presence of polycystic ovaries on ultrasound scan. Ultrasound findings of enlarged ovaries with multiple small cysts (10-12 or more of 2-9 mm in diameter) scattered around the periphery and highly echogenic stroma
排除标准
- •Including other causes of infertility diagnosed during infertility work up.
- •Patients refused to participate or to continue study.
- •Also, hepatic, cardiac, and hypotensive patients will be excluded from the study.
研究组 & 干预措施
Clomifene citrate and Amlodipine
Amlodipine 5mg tablet and Clomifene citrate 50 mg tablet once by mouth daily at morning starting from day number 5 of menstrual cycle till day number 9.
干预措施: Clomifene citrate ( clomid 50 mg ) (Drug)
Clomifene citrate and Amlodipine
Amlodipine 5mg tablet and Clomifene citrate 50 mg tablet once by mouth daily at morning starting from day number 5 of menstrual cycle till day number 9.
干预措施: Amlodipine (Drug)
Clomifene citrate
Clomifene citrate 50mg and once daily at morning starting from day number 5 of menstrual cycle till day number 9
干预措施: Clomifene citrate ( clomid 50 mg ) (Drug)
结局指标
主要结局
change in ovarian artery perfusion
时间窗: day number five and day number 9 of menstrual cycle
peak systolic velocity ( psv ) measured by doppler u/s
次要结局
- Number of mature follicle(day 14 of menstrual cycle)
- endometrial thickening(day number five and day number 9 of menstrual cycle)
研究者
Ahmed Fathy Ali Mohamed Ghanem
Resident of Obstetrics and Gynecology
Ain Shams Maternity Hospital