The Impact of Uterine Flushing With Human Chorionic Gonadotrophin Before Intrauterine Insemination on Pregnancy and Live Birth Rates in Women With Unexplained Infertility: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Unexplained Infertility
- Sponsor
- Ahmed Walid Anwar Murad
- Enrollment
- 210
- Primary Endpoint
- Live birth
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
A prospective randomized study included 210 women with Unexplained infertility subjected to combined ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
Detailed Description
A prospective randomized study included 210 patients with Unexplained infertility subjected to coupled ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
Investigators
Ahmed Walid Anwar Murad
Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine; Banha University
Benha University
Eligibility Criteria
Inclusion Criteria
- •Unexplained infertility (UI)
Exclusion Criteria
- •body mass index (BMI) ≥35 kg/m2,
- •Follicle Stimulating Hormone \>10 International Unit /Litter in early follicular phase,
- •diagnosed cause of infertility, menstrual cycle irregularity,
- •ovarian cysts,
- •sever cervical stenosis,
- •former IUI,
- •ongoing pregnancy and
- •renal or hepatic diseases were all the exclusion criteria.
Outcomes
Primary Outcomes
Live birth
Time Frame: 10 months of randomization
Defined as pregnancies maintained beyond 20 weeks of gestation
Secondary Outcomes
- Chemical pregnancy(One month after randomization)
- Clinical pregnancy(Two months after randomization)
- Adverse effects(one hour of the procedure)