Uterine Flushing With Human Chorionic Gonadotrophin and Unexplained Infertility
- Conditions
- Unexplained Infertility
- Registration Number
- NCT03461601
- Lead Sponsor
- Ahmed Walid Anwar Murad
- Brief Summary
A prospective randomized study included 210 women with Unexplained infertility subjected to combined ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
- Detailed Description
A prospective randomized study included 210 patients with Unexplained infertility subjected to coupled ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 210
- Unexplained infertility (UI)
- body mass index (BMI) ≥35 kg/m2,
- Follicle Stimulating Hormone >10 International Unit /Litter in early follicular phase,
- diagnosed cause of infertility, menstrual cycle irregularity,
- ovarian cysts,
- sever cervical stenosis,
- former IUI,
- ongoing pregnancy and
- renal or hepatic diseases were all the exclusion criteria.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Live birth 10 months of randomization Defined as pregnancies maintained beyond 20 weeks of gestation
- Secondary Outcome Measures
Name Time Method Chemical pregnancy One month after randomization Defined as positive serum pregnancy test
Clinical pregnancy Two months after randomization Defined by the presence of gestational sac with fetal heartbeats on ultrasound scan or histological identification of trophoblastic tissue.
Adverse effects one hour of the procedure Nausea, vomiting, and pain