The Impact of Uterine Flushing With Human Chorionic Gonadotrophin Before Intrauterine Insemination on Pregnancy and Live Birth Rates in Women With Unexplained Infertility: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 210
- 主要终点
- Live birth
研究概览
简要总结
A prospective randomized study included 210 women with Unexplained infertility subjected to combined ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
详细描述
A prospective randomized study included 210 patients with Unexplained infertility subjected to coupled ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
Vaginal flushing with 10 ml saline was performed in the control group
入排标准
- 年龄范围
- 18 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Unexplained infertility (UI)
排除标准
- •body mass index (BMI) ≥35 kg/m2,
- •Follicle Stimulating Hormone >10 International Unit /Litter in early follicular phase,
- •diagnosed cause of infertility, menstrual cycle irregularity,
- •ovarian cysts,
- •sever cervical stenosis,
- •former IUI,
- •ongoing pregnancy and
- •renal or hepatic diseases were all the exclusion criteria.
结局指标
主要结局
Live birth
时间窗: 10 months of randomization
Defined as pregnancies maintained beyond 20 weeks of gestation
次要结局
- Chemical pregnancy(One month after randomization)
- Clinical pregnancy(Two months after randomization)
- Adverse effects(one hour of the procedure)
研究者
Ahmed Walid Anwar Murad
Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine; Banha University
Benha University