Multimodal Imaging Analysis, SD-OCT and OCT Angiography, Retinal Variations Observed in Dialysis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- vascular density before hemodialysis
研究概览
简要总结
Little knowledge exist on the short and long-term ophthalmological effect of the dialysis. Some studies stated a variation of the thickness subfoveal choroidal before and after a session of dialyse as well as variations of the coat of optical fibers measured in OCT.
The Optical Coherence Tomography angiography OCT is a not invasive imaging technique which is now a part of examinations of investigation in imaging of retina. This technique allows to study the retinal macula vascularization without injection of contrast agent and thus allows to deepen the knowledge in medical domains where the exploration was to limited because of the invasive character of the examinations.
The hypothesis of this project is that hemodynamic change during the hemodialysis may lead fine variations of the retinal vascularization in the short-term (the day of the dialysis) but also in the longer term (over 1 year).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Indication of treatment by hemodialysis
- •First session of dialysis
- •Hemodialysis planned for 1 minimum year
排除标准
- •particular ophthalmological Histories: vitreo-retinal surgery, strong nearsightedness, chronic glaucoma
- •Unaffiliated in a national insurance scheme
结局指标
主要结局
vascular density before hemodialysis
时间窗: before hemodialysis
Analysis of the variation of the vascular densities in retinal macula in the central 6 mm
vascular density 1 hour after hemodialysis
时间窗: 1 hour after hemodialysis
Analysis of the variation of the vascular densities in retinal macula in the central 6 mm
次要结局
- vascular density 12 month after dialysis(12 month after dialysis)
- size of coat retinal optical fibers 1 hour after dialysis(1 hour after dialysis)
- vascular density 1 hour after dialysis(1 hour after dialysis)
- size of coat retinal optical fibers 12 month after dialysis(12 month after dialysis)
- size of coat retinal optical fibers before dialysis(before dialysis)
- vascular density 1 month after dialysis(1 month after dialysis)
- vascular density 6 month after dialysis(6 month after dialysis)
- size of coat retinal optical fibers 1 month after dialysis(1 month after dialysis)
- size of coat retinal optical fibers 3 month after dialysis(3 month after dialysis)
- size of coat retinal optical fibers 6 month after dialysis(6 month after dialysis)
- vascular density 3 month after dialysis(3 month after dialysis)
- vascular density before dialysis(before dialysis)