Omega-3 Fatty Acids to Combat Sarcopenia

Phase 1

Completed

• Conditions: Sarcopenia
• Interventions: Drug: Omega-3 fatty acids

• Registration Number: NCT02103842
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this study is to determine how omega-3 fatty acids influence muscle protein metabolism and mitochondrial physiology in the context of human aging.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2014-03-18
• Study First Submitted QC: 2014-04-01
• Study First Posted: 2014-04-04
• Primary Completion: 2015-07
• Study Completion: 2015-07
• Status Verified: 2015-12
• Last Update Submitted: 2015-12-22
• Last Update Posted: 2015-12-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Age 18-35 or 65-85 years

Exclusion Criteria

1. Current use of omega-3 nutritional supplements
2. Fasting plasma glucose ≥126 mg/dL
3. Active coronary artery disease
4. Participation in structured exercise (>3 times per week for 30 minutes or longer)
5. Smoking
6. Medications known to affect muscle metabolism (e.g., beta blockers, corticosteroids, tricyclic-antidepressants, benzodiazepines, opiates, barbiturates, anticoagulants)
7. Renal failure (serum creatinine > 1.5mg/dl)
8. Chronic active liver disease (Bilirubin > 17mmol/L, AST>144IU/L, or ALT>165IU/L)
9. Anti-coagulant therapy (warfarin/heparin)
10. INR >3
11. Use of systemic glucocorticoids
12. Chronic use of NSAIDS or aspirin
13. Pregnancy or breastfeeding
14. Alcohol consumption greater than 2 glasses/day
15. Hypothyroidism
16. Fish or shellfish allergy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Omega-3 fatty acids	Omega-3 fatty acids	Participants will take 3.9g/day of Eicosapentaenoic acid and docosahexaenoic acid for 4 months

Primary Outcome Measures

Name	Time	Method
Change in Muscle protein synthesis	Baseline and following 4 months intervention	Skeletal muscle protein synthesis will be measured from the rate of incorporation of infused amino acids measured by mass spectrometry.
Change in Muscle mitochondrial function	Baseline and following 4 months intervention	Mitochondrial function will be measured in isolated mitochondria by high-resolution respirometry.

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States