Prevention of delirium (mental confusion) in intensive care using low dose risperidone

Not Applicable

Completed

• Conditions: Delirium in the intensive care unit; Mental and Behavioural Disorders

• Registration Number: ISRCTN17375500
• Lead Sponsor: Vellore Christian Medical College Foundation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-11-30
• Study Start: 2021-01-19
• Last Update Posted: 30 March 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Adults (18>years old) admitted into the medical intensive care unit

Exclusion Criteria

1. No informed consent obtained
2. Neurological disease (including post-cardiopulmonary resuscitation patients)
3. Coma due to drug overdose
4. Alcohol withdrawal syndrome
5. Antipsychotic therapy over the last 30 days
6. Pregnancy/breast feeding
7. Documented delirium prior to ICU admission
8. Difficulty in CAM-ICU ssessment (serious auditory or visual disorders, severely mentally disabled; serious receptive aphasia)
9. Predicted ICU-stay less than one day
10. Moribund and not expected to survive two days
11. Known allergy to Risperidone
12. Severe haemodynamic instability (vasopressor dose/inotrope dose>20mcg/min)
13. Liver failure (Child-Pugh stage B or C)
14. Renal failure (Stage 3 KDIGO or above)

Study & Design

• Study Type: Interventional
• Study Design: Not specified