Prevention of Delirium in Intensive Care using low dose risperidone prophylaxis: arandomised placebo controlled trial
Not Applicable
- Conditions
- Health Condition 1: null- Adult patients admitted to the medical intensive care unit
- Registration Number
- CTRI/2018/10/015955
- Lead Sponsor
- Christian Medical College Vellore
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients admitted to the medical intensive care unit
Exclusion Criteria
No informed consent obtained
Neurological disease(including post-cardiac arrest patients)
Come due to drug overdose
Alcohol withdrawal
Antipsychotic therapy in the last 30 days
Pregnancy or breast feeding
Documented delirium prior to IUD admission
Difficulty in CAM ICU assessment (serious auditory or visual disorders, mentally disabled)
Expected ICU stay less than 1day
Moribund and not expected to survive 2 days
Known risperidone allergy
Severe hemodynamic instability requiring vasopressors more the 20mcg/min
Renal failure eGFR less than 30ml/min
Liver failure child Pugh B/C
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of delirium in the study patients as assessed by the CAM-ICU scoreTimepoint: During ICU stay
- Secondary Outcome Measures
Name Time Method Duration of ICU stay <br/ ><br>Duration of hospital stay <br/ ><br>Mortality at 28 daysTimepoint: Follow up till 28 days