Substitution of calcineurin inhibitors with sirolimus on left ventricular hypertrophy (LVH) of renal transplant recipients (RTR)

Completed

• Conditions: Chronic allograft nephropathy in renal transplant recipients; left ventricular hypertrophy; Injury, Occupational Diseases, Poisoning; Failure and rejection of transplanted organs and tissues

• Registration Number: ISRCTN54216890
• Lead Sponsor: San Martino University Hospital (Azienda Ospedaliera Universitaria San Martino) (Italy)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-05-12
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

1. Age 25-66 years, both males and females
2. Non diabetic RTR with biopsy-proven chronic allograft nephropathy
3. Patients who have received a single kidney in 2004

Exclusion Criteria

1. Diabetic RTR
2. Patients receiving kidney transplant from living donors
3. Patients receiving dual kidney allograft

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in left ventricular mass (LVMi) at 12 months

Secondary Outcome Measures

Name	Time	Method
Changes in serum creatinine as a measure of graft function at 12 months