Thorax Computed Tomography Severity Score and Outcome in COVID-19 Patients

• Conditions: COVID-19

• Registration Number: NCT04424849
• Lead Sponsor: Tepecik Training and Research Hospital

Brief Summary

The most common thorax Computed tomography (CT) findings are multifocal ground-glass opacities and peripheral consolidation in patients with COVID-19. Septal thickening, bronchiectasis, pleural thickening, and subpleural involvement may also be observed. Although these findings are not specific to COVID-19, the severity of pulmonary involvement is expected to be correlated with thorax CT findings.

Detailed Description

Thorax computed tomography severity score defined by Yang et al. can be used to evaluate the severity of pulmonary involvement in COVID-19 patients. We aimed to investigate whether the initial thorax computed tomography severity score can predict mechanical ventilation requirement and mortality in COVID-19 patients.

Study Timeline

• Study Start: 2020-03-15
• Status Verified: 2020-06
• Study First Submitted: 2020-06-08
• Study First Submitted QC: 2020-06-08
• Last Update Submitted: 2020-06-08
• Study First Posted: 2020-06-11
• Last Update Posted: 2020-06-11
• Primary Completion: 2020-06-15
• Study Completion: 2020-07-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age ≥ 18 years
• COVID-19 confirmed by positive RT-PCR and/or antibody testing
• CT scan at intensive care unit admission

Exclusion Criteria

• Loss of CT data
• Chronic lung disease findings by CT that may lead to misinterpretation
• RT-PCR results unavailable or negative
• Terminal cancer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Invasive respiratory support in patients with COVID-19	120 days	Whether Thorax CT findings predict invasive mechanical ventilation requirement of covid-19 patients

Secondary Outcome Measures

Name	Time	Method
Mortality in patients with COVID-19	120 days	Whether Thorax CT findings predict mortality of covid-19 patients

Trial Locations

Locations (1)

Tepecik Training and Research Hospital; 🇹🇷 Izmir, Izmir, Konak, Turkey