Study for the efficacy and mechanism of acupuncture and rTMS on the emotional cognitive regulation of major depression.
- Conditions
- Major depression disorder
- Registration Number
- ITMCTR2000003963
- Lead Sponsor
- Guangdong Hospital of Traditional Chinese Medicine (the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Second Clinical School of Guangzhou University of Chinese
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. Patients aged 18-65 years old;
2. The patients who meet the diagnostic criteria of Western medicine depression meet the diagnostic criteria of depression and liver depression and qi stagnation syndrome;
3. Patients with HAMD-17 score >= 17;
4. Patients who did not take antidepressant drugs at the first time;
5. Right handed subjects (according to Edinburgh Handedness scales);
6. The subjects who signed the informed consent form voluntarily participated in the study.
1. Patients who have taken any antidepressants or other antipsychotics in the past have received modified electroconvulsive therapy (ECT);
2. Patients with obvious suicidal tendency assessed by specialists;
3. Patients with serious medical diseases;
4. Patients with previous history of head trauma;
5. Patients with cognitive impairment (MMSE score < 17), schizophrenia, anxiety disorder, substance abuse or other mental disorders;
6. Patients with metal implants, such as cardiac pacemaker, deep brain stimulator, vagus nerve stimulator, vascular stent, etc;
7. Patients who are willing to be pregnant or are in pregnancy or lactation.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Event-related potential (ERP);HAMD;
- Secondary Outcome Measures
Name Time Method SF-36;