Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis

• Conditions: Sickle Cell Disease
• Interventions: Other: Evaluation of global longitudinal strain using routinely recorded echocardiography images

• Registration Number: NCT04864041
• Lead Sponsor: Bicetre Hospital

Brief Summary

Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non invasive technique that may allow us to observe such myocardial dysfunction. No such study has yet been conducted in patient hospitalised in intensive care unit. Our hypothesis is that strain alteration during vaso-occlusive crisis, if they do exist, can be correlated with other markers of myocardial injury such as troponin level or thoracic pain.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-01
• Status Verified: 2021-04
• Study First Submitted: 2021-04-23
• Study First Submitted QC: 2021-04-24
• Last Update Submitted: 2021-04-27
• Study First Posted: 2021-04-28
• Last Update Posted: 2021-04-29
• Primary Completion: 2023-12-01
• Study Completion: 2023-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Hospitalisation in an intensive care unit for vaso-occlusive crisis

Exclusion Criteria

• Pregnancy
• Individuals under guardianship
• Unsufficient echogenicity
• Thoracic pain prohibiting echocardiography assessment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients hospitalised in ICU for vaso-occlusive crisis	Evaluation of global longitudinal strain using routinely recorded echocardiography images	-

Primary Outcome Measures

Name	Time	Method
Global longitudinal strain	Day 2	Measure of global longitudinal strain using speckle tracking echocardiography

Secondary Outcome Measures

Name	Time	Method
Thoracic pain	Day 2	Numerical rating scale from 0 to 10 assessed by the patient
Troponine level	Day 2
Electrocardiogram QT interval	Day 2
Electrocardiogram ST elevation	Day 2
Electrocardiogram negative T waves	Day 2

Trial Locations

Locations (1)

Medical Intensive Care Unit; 🇫🇷 Le Kremlin-Bicêtre, France