Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis
- Conditions
- Sickle Cell Disease
- Registration Number
- NCT04864041
- Lead Sponsor
- Bicetre Hospital
- Brief Summary
Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non invasive technique that may allow us to observe such myocardial dysfunction. No such study has yet been conducted in patient hospitalised in intensive care unit. Our hypothesis is that strain alteration during vaso-occlusive crisis, if they do exist, can be correlated with other markers of myocardial injury such as troponin level or thoracic pain.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Hospitalisation in an intensive care unit for vaso-occlusive crisis
Exclusion Criteria
- Pregnancy
- Individuals under guardianship
- Unsufficient echogenicity
- Thoracic pain prohibiting echocardiography assessment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Global longitudinal strain Day 2 Measure of global longitudinal strain using speckle tracking echocardiography
- Secondary Outcome Measures
Name Time Method Thoracic pain Day 2 Numerical rating scale from 0 to 10 assessed by the patient
Troponine level Day 2 Electrocardiogram QT interval Day 2 Electrocardiogram ST elevation Day 2 Electrocardiogram negative T waves Day 2
Trial Locations
- Locations (1)
Medical Intensive Care Unit
🇫🇷Le Kremlin-Bicêtre, France
Medical Intensive Care Unit🇫🇷Le Kremlin-Bicêtre, FranceXavier Monnet, MD, PhDPrincipal Investigator