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Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis

Conditions
Sickle Cell Disease
Registration Number
NCT04864041
Lead Sponsor
Bicetre Hospital
Brief Summary

Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non invasive technique that may allow us to observe such myocardial dysfunction. No such study has yet been conducted in patient hospitalised in intensive care unit. Our hypothesis is that strain alteration during vaso-occlusive crisis, if they do exist, can be correlated with other markers of myocardial injury such as troponin level or thoracic pain.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
30
Inclusion Criteria
  • Hospitalisation in an intensive care unit for vaso-occlusive crisis
Exclusion Criteria
  • Pregnancy
  • Individuals under guardianship
  • Unsufficient echogenicity
  • Thoracic pain prohibiting echocardiography assessment

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Global longitudinal strainDay 2

Measure of global longitudinal strain using speckle tracking echocardiography

Secondary Outcome Measures
NameTimeMethod
Thoracic painDay 2

Numerical rating scale from 0 to 10 assessed by the patient

Troponine levelDay 2
Electrocardiogram QT intervalDay 2
Electrocardiogram ST elevationDay 2
Electrocardiogram negative T wavesDay 2

Trial Locations

Locations (1)

Medical Intensive Care Unit

🇫🇷

Le Kremlin-Bicêtre, France

Medical Intensive Care Unit
🇫🇷Le Kremlin-Bicêtre, France
Xavier Monnet, MD, PhD
Principal Investigator

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